Lee KSS - Search Results

1

Asymmetric Total Synthesis of 19,20-Epoxydocosapentaenoic Acid, a Bioactive Metabolite of Docosahexaenoic Acid.

Cinelli MA, Lee KSS. Cinelli MA, et al. Among authors: lee kss. J Org Chem. 2019 Dec 6;84(23):15362-15372. doi: 10.1021/acs.joc.9b02378. Epub 2019 Nov 21. J Org Chem. 2019. PMID: 31701741 Free PMC article.

2

Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids.

Cinelli MA, Yang J, Scharmen A, Woodman J, Karchalla LM, Lee KSS. Cinelli MA, et al. Among authors: lee kss. J Lipid Res. 2018 Nov;59(11):2237-2252. doi: 10.1194/jlr.D089136. Epub 2018 Sep 12. J Lipid Res. 2018. PMID: 30209076 Free PMC article.

3

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids.

Woodman JW, Cinelli MA, Scharmen-Burgdolf A, Lee KSS. Woodman JW, et al. Among authors: lee kss. J Vis Exp. 2019 Jun 28;(148):10.3791/59770. doi: 10.3791/59770. J Vis Exp. 2019. PMID: 31305515 Free PMC article.

4

Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation.

Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hwang SH, Kim D, Lee KSS, Xiao H, Hammock BD, Zhang G. Wang Y, et al. Among authors: lee kss. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8431-8436. doi: 10.1073/pnas.1916189117. Epub 2020 Mar 27. Proc Natl Acad Sci U S A. 2020. PMID: 32220957 Free PMC article.

5

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.

Sarparast M, Dattmore D, Alan J, Lee KSS. Sarparast M, et al. Among authors: lee kss. Nutrients. 2020 Nov 16;12(11):3523. doi: 10.3390/nu12113523. Nutrients. 2020. PMID: 33207662 Free PMC article. Review.

6

Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.

Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G. Wang W, et al. Among authors: lee kss. Cancer Res. 2019 Apr 15;79(8):1822-1830. doi: 10.1158/0008-5472.CAN-18-3221. Epub 2019 Feb 25. Cancer Res. 2019. PMID: 30803995 Free PMC article.

7

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. Barnych B, et al. Among authors: lee kss. Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b. Org Biomol Chem. 2017. PMID: 28470279 Free PMC article.

8

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.

Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. Lee KS, et al. J Med Chem. 2014 Aug 28;57(16):7016-30. doi: 10.1021/jm500694p. Epub 2014 Aug 11. J Med Chem. 2014. PMID: 25079952 Free PMC article.

9

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.

Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Sharma A, et al. Int J Mol Sci. 2016 May 18;17(5):751. doi: 10.3390/ijms17050751. Int J Mol Sci. 2016. PMID: 27213332 Free PMC article.

10

PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.

Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. Samokhvalov V, et al. Toxicol Lett. 2015 Jan 5;232(1):10-20. doi: 10.1016/j.toxlet.2014.09.029. Epub 2014 Oct 6. Toxicol Lett. 2015. PMID: 25300478 Free PMC article.

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