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Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis.
Jung SK, Ko Y, Yu KR, Kim JH, Lee JY, Chae CH, Ji S, Kim CH, Lee HK, Choi EB, Kim BY, Erikson RL, Chung SJ, Kim SJ. Jung SK, et al. Among authors: lee jy, lee hk. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2084-8. doi: 10.1016/j.bmcl.2012.01.011. Epub 2012 Jan 21. Bioorg Med Chem Lett. 2012. PMID: 22326397
Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Mathi GR, Kang CH, Lee HK, Achary R, Lee HY, Lee JY, Ha JD, Ahn S, Park CH, Lee CO, Hwang JY, Yun CS, Jung HJ, Cho SY, Kim HR, Kim P. Mathi GR, et al. Among authors: lee co, lee jy, lee hy, lee hk. Eur J Med Chem. 2017 Jan 27;126:536-549. doi: 10.1016/j.ejmech.2016.11.046. Epub 2016 Nov 24. Eur J Med Chem. 2017. PMID: 27915169
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