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5-Methoxy-α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.
Abiero A, Botanas CJ, Sayson LV, Custodio RJ, de la Peña JB, Kim M, Lee HJ, Seo JW, Ryu IS, Chang CM, Yang JS, Lee YS, Jang CG, Kim HJ, Cheong JH. Abiero A, et al. Among authors: lee ys, lee hj. Behav Brain Res. 2019 Feb 1;359:828-835. doi: 10.1016/j.bbr.2018.07.020. Epub 2018 Jul 24. Behav Brain Res. 2019. PMID: 30053461
The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors.
Sayson LV, Botanas CJ, Custodio RJP, Abiero A, Kim M, Lee HJ, Kim HJ, Yoo SY, Lee KW, Ryu HW, Acharya S, Kim KM, Lee YS, Cheong JH. Sayson LV, et al. Among authors: lee ys, lee kw, lee hj. Psychopharmacology (Berl). 2019 Jul;236(7):2201-2210. doi: 10.1007/s00213-019-05219-x. Epub 2019 Mar 19. Psychopharmacology (Berl). 2019. PMID: 30891619
25B-NBOMe, a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: Evidence of abuse potential.
Custodio RJP, Sayson LV, Botanas CJ, Abiero A, You KY, Kim M, Lee HJ, Yoo SY, Lee KW, Lee YS, Seo JW, Ryu IS, Kim HJ, Cheong JH. Custodio RJP, et al. Among authors: lee ys, lee kw, lee hj. Addict Biol. 2020 Nov;25(6):e12850. doi: 10.1111/adb.12850. Epub 2019 Nov 20. Addict Biol. 2020. PMID: 31749223
4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels.
Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, Kim HJ, Lee KW, Jeong Y, Seo JW, Ryu IS, Lee YS, Cheong JH. Abiero A, et al. Among authors: lee ys, lee kw, lee hj. Psychopharmacology (Berl). 2020 Mar;237(3):757-772. doi: 10.1007/s00213-019-05412-y. Epub 2019 Dec 11. Psychopharmacology (Berl). 2020. PMID: 31828394
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