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Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.
Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Chu YY, et al. Among authors: lee hh, lee s. Nat Cancer. 2022 Oct;3(10):1211-1227. doi: 10.1038/s43018-022-00438-2. Epub 2022 Oct 17. Nat Cancer. 2022. PMID: 36253486 Free PMC article.
Pirtobrutinib and venetoclax combination overcomes resistance to targeted and chimeric antigen receptor T-cell therapy in aggressive mantle cell lymphoma.
Liu Y, Yan F, Jiang VC, Li Y, Che Y, McIntosh J, Jordan A, Hou I, Nie L, Jin J, Wang W, Lee HH, Yao Y, Wang M. Liu Y, et al. Among authors: lee hh. Haematologica. 2023 May 1;108(5):1412-1416. doi: 10.3324/haematol.2022.282031. Haematologica. 2023. PMID: 36475521 Free PMC article. No abstract available.
Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma.
Jiang VC, Liu Y, Lian J, Huang S, Jordan A, Cai Q, Lin R, Yan F, McIntosh J, Li Y, Che Y, Chen Z, Vargas J, Badillo M, Bigcal JN, Lee HH, Wang W, Yao Y, Nie L, Flowers CR, Wang M. Jiang VC, et al. Among authors: lee hh. J Clin Invest. 2023 Feb 1;133(3):e165694. doi: 10.1172/JCI165694. J Clin Invest. 2023. PMID: 36719376 Free PMC article.
The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma.
Yan F, Jiang V, Jordan A, Che Y, Liu Y, Cai Q, Xue Y, Li Y, McIntosh J, Chen Z, Vargas J, Nie L, Yao Y, Lee HH, Wang W, Bigcal JR, Badillo M, Meena J, Flowers C, Zhou J, Zhao Z, Simon LM, Wang M. Yan F, et al. Among authors: lee hh. Exp Hematol Oncol. 2024 Feb 7;13(1):14. doi: 10.1186/s40164-024-00484-9. Exp Hematol Oncol. 2024. PMID: 38326887 Free PMC article.
2,474 results