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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H; NYGC ALS Consortium; Newcombe J, Gustavsson EK, Seddighi S, Reyes JF, Coon SL, Ramos D, Schiavo G, Fisher EMC, Raj T, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P. Brown AL, et al. Among authors: lee fcy. Nature. 2022 Mar;603(7899):131-137. doi: 10.1038/s41586-022-04436-3. Epub 2022 Feb 23. Nature. 2022. PMID: 35197628 Free PMC article.
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
Hallegger M, Chakrabarti AM, Lee FCY, Lee BL, Amalietti AG, Odeh HM, Copley KE, Rubien JD, Portz B, Kuret K, Huppertz I, Rau F, Patani R, Fawzi NL, Shorter J, Luscombe NM, Ule J. Hallegger M, et al. Among authors: lee fcy. Cell. 2021 Sep 2;184(18):4680-4696.e22. doi: 10.1016/j.cell.2021.07.018. Epub 2021 Aug 10. Cell. 2021. PMID: 34380047 Free PMC article.
Subcytoplasmic location of translation controls protein output.
Horste EL, Fansler MM, Cai T, Chen X, Mitschka S, Zhen G, Lee FCY, Ule J, Mayr C. Horste EL, et al. Among authors: lee fcy. Mol Cell. 2023 Dec 21;83(24):4509-4523.e11. doi: 10.1016/j.molcel.2023.11.025. Mol Cell. 2023. PMID: 38134885 Free article.
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.
Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, Lee FCY, Rusha E, Shaposhnikov D, Palo M, Merl-Pham J, Cacchiarelli D, Rogelj B, Hauck SM, von Mering C, Meissner A, Lickert H, Hirose T, Ule J, Drukker M. Modic M, et al. Among authors: lee fcy. Mol Cell. 2019 Jun 6;74(5):951-965.e13. doi: 10.1016/j.molcel.2019.03.041. Epub 2019 Apr 29. Mol Cell. 2019. PMID: 31047794 Free PMC article.
RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons.
Fernández-Moya SM, Ehses J, Bauer KE, Schieweck R, Chakrabarti AM, Lee FCY, Illig C, Luscombe NM, Harner M, Ule J, Kiebler MA. Fernández-Moya SM, et al. Among authors: lee fcy. Int J Mol Sci. 2021 Dec 1;22(23):13021. doi: 10.3390/ijms222313021. Int J Mol Sci. 2021. PMID: 34884825 Free PMC article.
23 results