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MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.
Lee C, Kim KH, Cohen P. Lee C, et al. Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20. Free Radic Biol Med. 2016. PMID: 27216708 Free PMC article. Review.
Two additional peptides reported to originate from the mtDNA, namely humanin (Hashimoto et al., 2001; Ikone et al., 2003; Guo et al., 2003) [1-3] and MOTS-c (mitochondrial ORF of the twelve S c) (Lee et al., 2015) [4], indicate a larger mitochondrial genetic …
Two additional peptides reported to originate from the mtDNA, namely humanin (Hashimoto et al., 2001; Ikone et al., 2003; Guo et al., 2003) …
Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.
D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. D'Souza RF, et al. Among authors: lee c. Aging (Albany NY). 2020 Mar 17;12(6):5244-5258. doi: 10.18632/aging.102944. Epub 2020 Mar 17. Aging (Albany NY). 2020. PMID: 32182209 Free PMC article.
Humanin: a harbinger of mitochondrial-derived peptides?
Lee C, Yen K, Cohen P. Lee C, et al. Trends Endocrinol Metab. 2013 May;24(5):222-8. doi: 10.1016/j.tem.2013.01.005. Epub 2013 Feb 8. Trends Endocrinol Metab. 2013. PMID: 23402768 Free PMC article.
IGF-I regulates the age-dependent signaling peptide humanin.
Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. Lee C, et al. Aging Cell. 2014 Oct;13(5):958-61. doi: 10.1111/acel.12243. Epub 2014 Jul 18. Aging Cell. 2014. PMID: 25040290 Free PMC article.
A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. Zempo H, et al. Among authors: lee c. Aging (Albany NY). 2021 Jan 19;13(2):1692-1717. doi: 10.18632/aging.202529. Epub 2021 Jan 19. Aging (Albany NY). 2021. PMID: 33468709 Free PMC article.
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