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974 results

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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. Ho JSY, et al. Among authors: lee ac. Cell. 2021 May 13;184(10):2618-2632.e17. doi: 10.1016/j.cell.2021.03.051. Epub 2021 Mar 30. Cell. 2021. PMID: 33836156 Free PMC article.
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction.
Lau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H. Lau SY, et al. Among authors: lee ac. Emerg Microbes Infect. 2020 Dec;9(1):837-842. doi: 10.1080/22221751.2020.1756700. Emerg Microbes Infect. 2020. PMID: 32301390 Free PMC article.
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.
Yang D, Chu H, Hou Y, Chai Y, Shuai H, Lee AC, Zhang X, Wang Y, Hu B, Huang X, Yuen TT, Cai JP, Zhou J, Yuan S, Zhang AJ, Chan JF, Yuen KY. Yang D, et al. Among authors: lee ac. J Infect Dis. 2020 Aug 4;222(5):734-745. doi: 10.1093/infdis/jiaa356. J Infect Dis. 2020. PMID: 32563187 Free PMC article.
SARS-CoV-2 infects human neural progenitor cells and brain organoids.
Zhang BZ, Chu H, Han S, Shuai H, Deng J, Hu YF, Gong HR, Lee AC, Zou Z, Yau T, Wu W, Hung IF, Chan JF, Yuen KY, Huang JD. Zhang BZ, et al. Among authors: lee ac. Cell Res. 2020 Oct;30(10):928-931. doi: 10.1038/s41422-020-0390-x. Epub 2020 Aug 4. Cell Res. 2020. PMID: 32753756 Free PMC article. No abstract available.
Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model.
Li C, Chen YX, Liu FF, Lee AC, Zhao Y, Ye ZH, Cai JP, Chu H, Zhang RQ, Chan KH, Chiu KH, Lung DC, Sridhar S, Hung IF, To KK, Zhang AJ, Chan JF, Yuen KY. Li C, et al. Among authors: lee ac. Clin Infect Dis. 2021 Aug 2;73(3):e719-e734. doi: 10.1093/cid/ciab083. Clin Infect Dis. 2021. PMID: 33515458 Free PMC article.
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Yuan S, et al. Among authors: lee ac. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. Nature. 2021. PMID: 33727703
974 results