Lecomte M - Search Results

1

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Buchstaller HP, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, Dong L, Fuchß T, Germann M, Knehans T, Krier M, Lecomte M, Müller D, Müller SR, Leuthner B, Lindemann R, Musil D, Nowak M, Reither V, Rettig C, Schindler CEM, Pakulska U, Spuck D, Wegener A, Zarębski A. Buchstaller HP, et al. Among authors: lecomte m. J Med Chem. 2023 Jul 13;66(13):8666-8686. doi: 10.1021/acs.jmedchem.3c00332. Epub 2023 Jul 5. J Med Chem. 2023. PMID: 37403966

2

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.

Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Valeur E, et al. Among authors: lecomte m. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi: 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22901389

3

Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Roche D, et al. Among authors: lecomte m. Bioorg Med Chem Lett. 2009 May 15;19(10):2674-8. doi: 10.1016/j.bmcl.2009.03.140. Epub 2009 Apr 1. Bioorg Med Chem Lett. 2009. PMID: 19395260

4

Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.

Lepifre F, Christmann-Franck S, Roche D, Leriche C, Carniato D, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Lepifre F, et al. Among authors: lecomte m. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3682-5. doi: 10.1016/j.bmcl.2009.02.123. Epub 2009 Mar 5. Bioorg Med Chem Lett. 2009. PMID: 19450980

5

Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.

Petersson C, Papasouliotis O, Lecomte M, Badolo L, Dolgos H. Petersson C, et al. Among authors: lecomte m. Xenobiotica. 2020 Mar;50(3):270-279. doi: 10.1080/00498254.2019.1625084. Epub 2019 Jun 19. Xenobiotica. 2020. PMID: 31215316

6

Identification of solubility-limited absorption of oral anticancer drugs using PBPK modeling based on rat PK and its relevance to human.

Fink C, Lecomte M, Badolo L, Wagner K, Mäder K, Peters SA. Fink C, et al. Among authors: lecomte m. Eur J Pharm Sci. 2020 Sep 1;152:105431. doi: 10.1016/j.ejps.2020.105431. Epub 2020 Jun 18. Eur J Pharm Sci. 2020. PMID: 32562690 Free article.

7

Revealing the dynamics and mechanisms of bacterial interactions in cheese production with metabolic modelling.

Lecomte M, Cao W, Aubert J, Sherman DJ, Falentin H, Frioux C, Labarthe S. Lecomte M, et al. Metab Eng. 2024 May;83:24-38. doi: 10.1016/j.ymben.2024.02.014. Epub 2024 Mar 8. Metab Eng. 2024. PMID: 38460783 Free article.

8

Community-scale models of microbiomes: Articulating metabolic modelling and metagenome sequencing.

Cerk K, Ugalde-Salas P, Nedjad CG, Lecomte M, Muller C, Sherman DJ, Hildebrand F, Labarthe S, Frioux C. Cerk K, et al. Among authors: lecomte m. Microb Biotechnol. 2024 Jan;17(1):e14396. doi: 10.1111/1751-7915.14396. Epub 2024 Jan 20. Microb Biotechnol. 2024. PMID: 38243750 Free PMC article. Review.

9

Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model.

Lahlou G, Calvet C, Simon F, Michel V, Alciato L, Plion B, Boutet de Monvel J, Lecomte MJ, Beraneck M, Petit C, Safieddine S. Lahlou G, et al. Among authors: lecomte mj. JCI Insight. 2024 Feb 8;9(3):e169504. doi: 10.1172/jci.insight.169504. JCI Insight. 2024. PMID: 38194286 Free PMC article.

10

Impact of clonal lineages on susceptibility of Staphylococcus lugdunensis to chlorhexidine digluconate and chloride benzalkonium.

Destruel L, Lecomte M, Grand M, Leoz M, Pestel-Caron M, Dahyot S. Destruel L, et al. Among authors: lecomte m. BMC Microbiol. 2023 Nov 13;23(1):337. doi: 10.1186/s12866-023-03088-1. BMC Microbiol. 2023. PMID: 37957548 Free PMC article.

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