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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity.
Sum E, Rapp M, Fröbel P, Le Clech M, Dürr H, Giusti AM, Perro M, Speziale D, Kunz L, Menietti E, Brünker P, Hopfer U, Lechmann M, Sobieniecki A, Appelt B, Adelfio R, Nicolini V, Freimoser-Grundschober A, Jordaan W, Labiano S, Weber F, Emrich T, Christen F, Essig B, Romero P, Trumpfheller C, Umaña P. Sum E, et al. Among authors: lechmann m. Clin Cancer Res. 2021 Jul 15;27(14):4036-4053. doi: 10.1158/1078-0432.CCR-20-4001. Epub 2021 Mar 26. Clin Cancer Res. 2021. PMID: 33771854
Comparative assessment of immune complex-mediated hypersensitivity reactions with biotherapeutics in the non-human primate: Critical parameters, safety and lessons for future studies.
Kronenberg S, Husar E, Schubert C, Freichel C, Emrich T, Lechmann M, Giusti AM, Regenass F. Kronenberg S, et al. Among authors: lechmann m. Regul Toxicol Pharmacol. 2017 Aug;88:125-137. doi: 10.1016/j.yrtph.2017.06.004. Epub 2017 Jun 15. Regul Toxicol Pharmacol. 2017. PMID: 28624430
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy.
Bauss F, Lechmann M, Krippendorff BF, Staack R, Herting F, Festag M, Imhof-Jung S, Hesse F, Pompiati M, Kollmorgen G, da Silva Mateus Seidl R, Bossenmaier B, Lau W, Schantz C, Stracke JO, Brinkmann U, Onda M, Pastan I, Bosslet K, Niederfellner G. Bauss F, et al. Among authors: lechmann m. Mol Oncol. 2016 Oct;10(8):1317-29. doi: 10.1016/j.molonc.2016.07.003. Epub 2016 Jul 14. Mol Oncol. 2016. PMID: 27507537 Free PMC article.
Translating pharmacology models effectively to predict therapeutic benefit.
Dudal S, Bissantz C, Caruso A, David-Pierson P, Driessen W, Koller E, Krippendorff BF, Lechmann M, Olivares-Morales A, Paehler A, Rynn C, Türck D, Van De Vyver A, Wang K, Winther L. Dudal S, et al. Among authors: lechmann m. Drug Discov Today. 2022 Jun;27(6):1604-1621. doi: 10.1016/j.drudis.2022.03.009. Epub 2022 Mar 15. Drug Discov Today. 2022. PMID: 35304340 Free article. Review.
Vaccination trial with HPV16 L1E7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3).
Kaufmann AM, Nieland JD, Jochmus I, Baur S, Friese K, Gabelsberger J, Gieseking F, Gissmann L, Glasschröder B, Grubert T, Hillemanns P, Höpfl R, Ikenberg H, Schwarz J, Karrasch M, Knoll A, Küppers V, Lechmann M, Lelle RJ, Meissner H, Müller RT, Pawlita M, Petry KU, Pilch H, Walek E, Schneider A. Kaufmann AM, et al. Among authors: lechmann m. Int J Cancer. 2007 Dec 15;121(12):2794-800. doi: 10.1002/ijc.23022. Int J Cancer. 2007. PMID: 17721997 Free article. Clinical Trial.
Immune responses in hepatitis C virus infection.
Spengler U, Lechmann M, Irrgang B, Dumoulin FL, Sauerbruch T. Spengler U, et al. Among authors: lechmann m. J Hepatol. 1996;24(2 Suppl):20-5. J Hepatol. 1996. PMID: 8836885 Review.
57 results