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Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR. Schwitalla S, et al. Among authors: lechel a. Cancer Cell. 2013 Jan 14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273920 Free article.
Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL. Kleger A, et al. Among authors: lechel a. Gastroenterology. 2012 Apr;142(4):907-17. doi: 10.1053/j.gastro.2012.01.004. Epub 2012 Jan 12. Gastroenterology. 2012. PMID: 22245845
Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response.
Frappart PO, Walter K, Gout J, Beutel AK, Morawe M, Arnold F, Breunig M, Barth TF, Marienfeld R, Schulte L, Ettrich T, Hackert T, Svinarenko M, Rösler R, Wiese S, Wiese H, Perkhofer L, Müller M, Lechel A, Sainz B Jr, Hermann PC, Seufferlein T, Kleger A. Frappart PO, et al. Among authors: lechel a. United European Gastroenterol J. 2020 Jun;8(5):594-606. doi: 10.1177/2050640620905183. Epub 2020 Feb 19. United European Gastroenterol J. 2020. PMID: 32213029 Free PMC article.
Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
Armacki M, Polaschek S, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T. Armacki M, et al. Among authors: lechel a. Gastroenterology. 2020 Sep;159(3):1019-1035.e22. doi: 10.1053/j.gastro.2020.05.052. Epub 2020 May 22. Gastroenterology. 2020. PMID: 32446697 Free article.
p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model.
Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD, Marquardt JU, Saborowski M, Saborowski A, Vogel A. Buitrago-Molina LE, et al. Among authors: lechel a. Cell Mol Gastroenterol Hepatol. 2021;11(5):1387-1404. doi: 10.1016/j.jcmgh.2021.01.006. Epub 2021 Jan 21. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33484913 Free PMC article.
CARD9 Forms an Alternative CBM Complex in Richter Syndrome.
Maier J, Lechel A, Marienfeld R, Barth TFE, Möller P, Mellert K. Maier J, et al. Among authors: lechel a. Cancers (Basel). 2022 Jan 21;14(3):531. doi: 10.3390/cancers14030531. Cancers (Basel). 2022. PMID: 35158799 Free PMC article.
69 results