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Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity.
Kouba S, Braire J, Félix R, Chantôme A, Jaffrès PA, Lebreton J, Dubreuil D, Pipelier M, Zhang X, Trebak M, Vandier C, Mathé-Allainmat M, Potier-Cartereau M. Kouba S, et al. Among authors: lebreton j. Eur J Med Chem. 2020 Jan 15;186:111854. doi: 10.1016/j.ejmech.2019.111854. Epub 2019 Nov 9. Eur J Med Chem. 2020. PMID: 31753515
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.
Sengmany S, Sitter M, Léonel E, Le Gall E, Loirand G, Martens T, Dubreuil D, Dilasser F, Rousselle M, Sauzeau V, Lebreton J, Pipelier M, Le Guével R. Sengmany S, et al. Among authors: lebreton j. Bioorg Med Chem Lett. 2019 Mar 1;29(5):755-760. doi: 10.1016/j.bmcl.2018.12.050. Epub 2018 Dec 23. Bioorg Med Chem Lett. 2019. PMID: 30655216 Free article.
3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation.
Golten S, Patinec A, Akoumany K, Rocher J, Graton J, Jacquemin D, Le Questel JY, Tessier A, Lebreton J, Blot V, Pipelier M, Douillard JY, Le Pendu J, Linclau B, Dubreuil D. Golten S, et al. Among authors: lebreton j. Eur J Med Chem. 2019 Sep 15;178:195-213. doi: 10.1016/j.ejmech.2019.05.069. Epub 2019 May 29. Eur J Med Chem. 2019. PMID: 31185411
3-fluoro- and 3,3-difluoro-3,4-dideoxy-KRN7000 analogues as new potent immunostimulator agents: total synthesis and biological evaluation in human invariant natural killer T cells and mice.
Hunault J, Diswall M, Frison JC, Blot V, Rocher J, Marionneau-Lambot S, Oullier T, Douillard JY, Guillarme S, Saluzzo C, Dujardin G, Jacquemin D, Graton J, Le Questel JY, Evain M, Lebreton J, Dubreuil D, Le Pendu J, Pipelier M. Hunault J, et al. Among authors: lebreton j. J Med Chem. 2012 Feb 9;55(3):1227-41. doi: 10.1021/jm201368m. Epub 2012 Feb 1. J Med Chem. 2012. PMID: 22243602
Synthesis of bicyclonucleosides having a C-C bridge.
Lebreton J, Escudier JM, Arzel L, Len C. Lebreton J, et al. Chem Rev. 2010 Jun 9;110(6):3371-418. doi: 10.1021/cr800465j. Chem Rev. 2010. PMID: 20235582 Review. No abstract available.
Synthesis of 3'-O2-(azaheterocycle)-thymidines.
Prestat G, Dubreuil D, Adjou A, Pradère JP, Lebreton J, Evers M, Henin Y. Prestat G, et al. Among authors: lebreton j. Nucleosides Nucleotides Nucleic Acids. 2000 Apr;19(4):735-48. doi: 10.1080/15257770008035021. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10960032
240 results