Lebek S - Search Results

1

Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease.

Lebek S, Chemello F, Caravia XM, Tan W, Li H, Chen K, Xu L, Liu N, Bassel-Duby R, Olson EN. Lebek S, et al. Science. 2023 Jan 13;379(6628):179-185. doi: 10.1126/science.ade1105. Epub 2023 Jan 12. Science. 2023. PMID: 36634166 Free PMC article.

2

Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice.

Lebek S, Caravia XM, Chemello F, Tan W, McAnally JR, Chen K, Xu L, Liu N, Bassel-Duby R, Olson EN. Lebek S, et al. Circulation. 2023 Nov 7;148(19):1490-1504. doi: 10.1161/CIRCULATIONAHA.123.065117. Epub 2023 Sep 15. Circulation. 2023. PMID: 37712250 Free article.

3

Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.

Neef S, Steffens A, Pellicena P, Mustroph J, Lebek S, Ort KR, Schulman H, Maier LS. Neef S, et al. Among authors: lebek s. J Mol Cell Cardiol. 2018 Feb;115:73-81. doi: 10.1016/j.yjmcc.2017.12.015. Epub 2017 Dec 30. J Mol Cell Cardiol. 2018. PMID: 29294328 Free PMC article.

4

SR Ca²⁺-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.

Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S. Mustroph J, et al. Among authors: lebek s. J Mol Cell Cardiol. 2018 Mar;116:81-90. doi: 10.1016/j.yjmcc.2018.02.002. Epub 2018 Feb 3. J Mol Cell Cardiol. 2018. PMID: 29410242 Free article.

5

Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart.

Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, Maier LS, Wagner S. Trum M, et al. Among authors: lebek s. Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1347-H1357. doi: 10.1152/ajpheart.00182.2020. Epub 2020 Oct 9. Am J Physiol Heart Circ Physiol. 2020. PMID: 33035439 Free PMC article.

6

A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.

Lebek S, Hegner P, Schach C, Reuthner K, Tafelmeier M, Maier LS, Arzt M, Wagner S. Lebek S, et al. PLoS One. 2020 Dec 10;15(12):e0243844. doi: 10.1371/journal.pone.0243844. eCollection 2020. PLoS One. 2020. PMID: 33301470 Free PMC article.

7

CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea.

Hegner P, Lebek S, Schaner B, Ofner F, Gugg M, Maier LS, Arzt M, Wagner S. Hegner P, et al. Among authors: lebek s. Antioxidants (Basel). 2023 Jan 29;12(2):315. doi: 10.3390/antiox12020315. Antioxidants (Basel). 2023. PMID: 36829874 Free PMC article.

8

The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.

Lebek S, Plößl A, Baier M, Mustroph J, Tarnowski D, Lücht CM, Schopka S, Flörchinger B, Schmid C, Zausig Y, Pagratis N, Marchand B, Koltun DO, Hung WK, Ahmadyar S, Belardinelli L, Maier LS, Wagner S. Lebek S, et al. J Mol Cell Cardiol. 2018 May;118:159-168. doi: 10.1016/j.yjmcc.2018.03.020. Epub 2018 Mar 31. J Mol Cell Cardiol. 2018. PMID: 29614261

9

Enhanced CaMKII-Dependent Late I_Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.

Lebek S, Pichler K, Reuthner K, Trum M, Tafelmeier M, Mustroph J, Camboni D, Rupprecht L, Schmid C, Maier LS, Arzt M, Wagner S. Lebek S, et al. Circ Res. 2020 Feb 28;126(5):603-615. doi: 10.1161/CIRCRESAHA.119.315755. Epub 2020 Jan 6. Circ Res. 2020. PMID: 31902278 Free article. Clinical Trial.

10

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.

Pabel S, Mustroph J, Stehle T, Lebek S, Dybkova N, Keyser A, Rupprecht L, Wagner S, Neef S, Maier LS, Sossalla S. Pabel S, et al. Among authors: lebek s. Europace. 2020 Jul 1;22(7):1111-1118. doi: 10.1093/europace/euaa079. Europace. 2020. PMID: 32413138

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