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Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW. Mousnier A, et al. Among authors: leatherbarrow rj. Nat Chem. 2018 Jun;10(6):599-606. doi: 10.1038/s41557-018-0039-2. Epub 2018 May 14. Nat Chem. 2018. PMID: 29760414 Free PMC article.
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Wright MH, et al. Among authors: leatherbarrow rj. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. Nat Chem. 2014. PMID: 24451586 Free PMC article.
Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.
Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Bell AS, et al. Among authors: leatherbarrow rj. J Med Chem. 2020 Jul 23;63(14):7740-7765. doi: 10.1021/acs.jmedchem.0c00570. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32575985 Free PMC article.
105 results