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Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP. McLeod B, et al. Among authors: leaf em. Immunity. 2022 Sep 13;55(9):1680-1692.e8. doi: 10.1016/j.immuni.2022.07.015. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977542 Free PMC article.
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus.
Lee J, Zepeda SK, Park YJ, Taylor AL, Quispe J, Stewart C, Leaf EM, Treichel C, Corti D, King NP, Starr TN, Veesler D. Lee J, et al. Among authors: leaf em. Cell Host Microbe. 2023 Dec 13;31(12):1961-1973.e11. doi: 10.1016/j.chom.2023.10.018. Epub 2023 Nov 20. Cell Host Microbe. 2023. PMID: 37989312 Free article.
Top-down design of protein architectures with reinforcement learning.
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sánchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D. Lutz ID, et al. Among authors: leaf em. Science. 2023 Apr 21;380(6642):266-273. doi: 10.1126/science.adf6591. Epub 2023 Apr 20. Science. 2023. PMID: 37079676
In vivo selection of synthetic nucleocapsids for tissue targeting.
Olshefsky A, Benasutti H, Sylvestre M, Butterfield GL, Rocklin GJ, Richardson C, Hicks DR, Lajoie MJ, Song K, Leaf E, Treichel C, Decarreau J, Ke S, Kher G, Carter L, Chamberlain JS, Baker D, King NP, Pun SH. Olshefsky A, et al. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2306129120. doi: 10.1073/pnas.2306129120. Epub 2023 Nov 8. Proc Natl Acad Sci U S A. 2023. PMID: 37939083 Free PMC article.
Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.
Dharmarajan S, Speer MY, Pierce K, Lally J, Leaf EM, Lin ME, Scatena M, Giachelli CM. Dharmarajan S, et al. Among authors: leaf em. Front Cardiovasc Med. 2021 Oct 29;8:687210. doi: 10.3389/fcvm.2021.687210. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34778386 Free PMC article.
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