Le Hegarat L - Search Results

1

In vivo genotoxicity testing strategies: Report from the 8th International Workshop on Genotoxicity Testing (IWGT).

Beevers C, Uno Y, Meurer K, Hamada S, Hashimoto K, Kirkland D, LeBaron MJ, Le Curieux F, Le Hegarat L, Martus HJ, Masumura K, Ohyama W, Roberts DJ, Vasquez M, Whitwell J, Witt KL. Beevers C, et al. Among authors: le hegarat l. Environ Mol Mutagen. 2023 Nov 9. doi: 10.1002/em.22578. Online ahead of print. Environ Mol Mutagen. 2023. PMID: 37942839 Review.

2

Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.

Bellamri M, Le Hegarat L, Turesky RJ, Langouët S. Bellamri M, et al. Among authors: le hegarat l. Chem Res Toxicol. 2017 Feb 20;30(2):657-668. doi: 10.1021/acs.chemrestox.6b00394. Epub 2016 Dec 15. Chem Res Toxicol. 2017. PMID: 27976871 Free PMC article.

3

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Alarcan J, Dubreil E, Huguet A, Aráoz R, Brée F, Bouaita B, Hurtaud-Pessel D, Braeuning A, Hessel-Pras S, Lampen A, Le Hégarat L, Fessard V. Alarcan J, et al. Among authors: le hegarat l. Toxicol Lett. 2019 Jun 1;307:17-25. doi: 10.1016/j.toxlet.2019.02.012. Epub 2019 Feb 27. Toxicol Lett. 2019. PMID: 30825503

4

Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450.

Alarcan J, Dubreil E, Huguet A, Hurtaud-Pessel D, Hessel-Pras S, Lampen A, Fessard V, Le Hegarat L. Alarcan J, et al. Among authors: le hegarat l. Toxins (Basel). 2017 Jul 5;9(7):212. doi: 10.3390/toxins9070212. Toxins (Basel). 2017. PMID: 28678150 Free PMC article.

5

In vitro genotoxicity potential investigation of 7 oxy-PAHs.

Clergé A, Le Goff J, Brotin E, Abeillard E, Vaudorne I, Denoyelle C, Le Hegarat L, Delépée R. Clergé A, et al. Among authors: le hegarat l. Environ Mol Mutagen. 2023 Mar;64(3):176-186. doi: 10.1002/em.22531. Epub 2023 Feb 22. Environ Mol Mutagen. 2023. PMID: 36757094

6

Hydrogen inhalation: in vivo rat genotoxicity tests.

Salomez-Ihl C, Tanguy S, Alcaraz JP, Davin C, Pascal-Moussellard V, Jabeur M, Bedouch P, Le Hegarat L, Fessard V, Blier AL, Huet S, Cinquin P, Boucher F. Salomez-Ihl C, et al. Among authors: le hegarat l. Mutat Res Genet Toxicol Environ Mutagen. 2024 Feb-Mar;894:503736. doi: 10.1016/j.mrgentox.2024.503736. Epub 2024 Feb 1. Mutat Res Genet Toxicol Environ Mutagen. 2024. PMID: 38432775

7

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.

Le Hegarat L, Dumont J, Josse R, Huet S, Lanceleur R, Mourot A, Poul JM, Guguen-Guillouzo C, Guillouzo A, Fessard V. Le Hegarat L, et al. Mutagenesis. 2010 Nov;25(6):555-60. doi: 10.1093/mutage/geq039. Epub 2010 Jul 30. Mutagenesis. 2010. PMID: 20675360

8

A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.

Le Hégarat L, Huet S, Fessard V. Le Hégarat L, et al. Mutagenesis. 2012 Nov;27(6):631-6. doi: 10.1093/mutage/ges028. Epub 2012 Jul 27. Mutagenesis. 2012. PMID: 22844081

9

Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity.

Le Hégarat L, Mourot A, Huet S, Vasseur L, Camus S, Chesné C, Fessard V. Le Hégarat L, et al. Toxicol Sci. 2014 Apr;138(2):300-9. doi: 10.1093/toxsci/kfu004. Epub 2014 Jan 15. Toxicol Sci. 2014. PMID: 24431211

10

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.

Bellamri M, Le Hegarat L, Vernhet L, Baffet G, Turesky RJ, Langouët S. Bellamri M, et al. Among authors: le hegarat l. Environ Mol Mutagen. 2016 Dec;57(9):656-667. doi: 10.1002/em.22059. Epub 2016 Nov 1. Environ Mol Mutagen. 2016. PMID: 27801952 Free PMC article.

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