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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM. Wang Z, et al. Among authors: le ct. Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12. Nat Med. 2019. PMID: 30420753 Free PMC article.
Obesity as an immune-modifying factor in cancer immunotherapy.
Canter RJ, Le CT, Beerthuijzen JMT, Murphy WJ. Canter RJ, et al. Among authors: le ct. J Leukoc Biol. 2018 Sep;104(3):487-497. doi: 10.1002/JLB.5RI1017-401RR. Epub 2018 May 15. J Leukoc Biol. 2018. PMID: 29762866 Free PMC article. Review.
PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment.
Le CT, Khuat LT, Caryotakis SE, Wang M, Dunai C, Nguyen AV, Vick LV, Stoffel KM, Blazar BR, Monjazeb AM, Murphy WJ, Soulika AM. Le CT, et al. Front Immunol. 2020 Oct 29;11:590568. doi: 10.3389/fimmu.2020.590568. eCollection 2020. Front Immunol. 2020. PMID: 33193426 Free PMC article.
Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ. Khuat LT, et al. Among authors: le ct. Sci Transl Med. 2020 Nov 25;12(571):eaay7713. doi: 10.1126/scitranslmed.aay7713. Sci Transl Med. 2020. PMID: 33239390 Free PMC article.
Regulation of human and mouse bystander T cell activation responses by PD-1.
Le CT, Vick LV, Collins C, Dunai C, Sheng MK, Khuat LT, Barao I, Judge SJ, Aguilar EG, Curti B, Dave M, Longo DL, Blazar BR, Canter RJ, Monjazeb AM, Murphy WJ. Le CT, et al. JCI Insight. 2023 Sep 22;8(18):e173287. doi: 10.1172/jci.insight.173287. JCI Insight. 2023. PMID: 37737264 Free PMC article.
Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation.
Estes ML, Prendergast K, MacMahon JA, Cameron S, Aboubechara JP, Farrelly K, Sell GL, Haapanen L, Schauer JD, Horta A, Shaffer IC, Le CT, Kincheloe GN, Tan DJ, van der List D, Bauman MD, Carter CS, Van de Water J, McAllister AK. Estes ML, et al. Among authors: le ct. Brain Behav Immun. 2020 Aug;88:619-630. doi: 10.1016/j.bbi.2020.04.061. Epub 2020 Apr 23. Brain Behav Immun. 2020. PMID: 32335198 Free PMC article.
Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors.
Martínez-Cerdeño V, Barrilleaux BL, McDonough A, Ariza J, Yuen BTK, Somanath P, Le CT, Steward C, Horton-Sparks K, Knoepfler PS. Martínez-Cerdeño V, et al. Among authors: le ct. Stem Cells Dev. 2017 Oct 1;26(19):1409-1423. doi: 10.1089/scd.2017.0059. Epub 2017 Aug 22. Stem Cells Dev. 2017. PMID: 28693365 Free PMC article.
241 results