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Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes.
Yang CH, Ann-Onda D, Lin X, Fynch S, Nadarajah S, Pappas EG, Liu X, Scott JW, Oakhill JS, Galic S, Shi Y, Moreno-Asso A, Smith C, Loudovaris T, Levinger I, Eizirik DL, Laybutt DR, Herzog H, Thomas HE, Loh K. Yang CH, et al. Among authors: laybutt dr. Mol Metab. 2022 Jan;55:101413. doi: 10.1016/j.molmet.2021.101413. Epub 2021 Dec 7. Mol Metab. 2022. PMID: 34890851 Free PMC article.
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.
Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Cheng K, et al. Among authors: laybutt dr. J Clin Invest. 2010 Jun;120(6):2171-83. doi: 10.1172/JCI35846. Epub 2010 May 3. J Clin Invest. 2010. PMID: 20440072 Free PMC article.
Inhibition of Y1 receptor signaling improves islet transplant outcome.
Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H. Loh K, et al. Among authors: laybutt dr. Nat Commun. 2017 Sep 8;8(1):490. doi: 10.1038/s41467-017-00624-2. Nat Commun. 2017. PMID: 28887564 Free PMC article.
Evidence against a role for NLRP3-driven islet inflammation in db/db mice.
Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA. Kammoun HL, et al. Among authors: laybutt dr. Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7. Mol Metab. 2018. PMID: 29478918 Free PMC article.
82 results