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Elucidating the role of N-acetylglucosamine in Group A Carbohydrate for the development of an effective glycoconjugate vaccine against Group A Streptococcus.
Pitirollo O, Di Benedetto R, Henriques P, Gasperini G, Mancini F, Carducci M, Massai L, Rossi O, Volbeda AG, Codée JDC, Berlanda Scorza F, Moriel DG, Necchi F, Lay L, Adamo R, Micoli F. Pitirollo O, et al. Among authors: lay l. Carbohydr Polym. 2023 Jul 1;311:120736. doi: 10.1016/j.carbpol.2023.120736. Epub 2023 Feb 23. Carbohydr Polym. 2023. PMID: 37028871 Free article.
A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A.
Enotarpi J, Tontini M, Balocchi C, van der Es D, Auberger L, Balducci E, Carboni F, Proietti D, Casini D, Filippov DV, Overkleeft HS, van der Marel GA, Colombo C, Romano MR, Berti F, Costantino P, Codeé JDC, Lay L, Adamo R. Enotarpi J, et al. Among authors: lay l. Nat Commun. 2020 Sep 7;11(1):4434. doi: 10.1038/s41467-020-18279-x. Nat Commun. 2020. PMID: 32895393 Free PMC article.
Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens.
Oldrini D, Fiebig T, Romano MR, Proietti D, Berger M, Tontini M, De Ricco R, Santini L, Morelli L, Lay L, Gerardy-Schahn R, Berti F, Adamo R. Oldrini D, et al. Among authors: lay l. ACS Chem Biol. 2018 Apr 20;13(4):984-994. doi: 10.1021/acschembio.7b01057. Epub 2018 Mar 1. ACS Chem Biol. 2018. PMID: 29481045 Free article.
Publisher Correction: A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A.
Enotarpi J, Tontini M, Balocchi C, van der Es D, Auberger L, Balducci E, Carboni F, Proietti D, Casini D, Filippov DV, Overkleeft HS, van der Marel GA, Colombo C, Romano MR, Berti F, Costantino P, Codeé JDC, Lay L, Adamo R. Enotarpi J, et al. Among authors: lay l. Nat Commun. 2020 Nov 25;11(1):6155. doi: 10.1038/s41467-020-20120-4. Nat Commun. 2020. PMID: 33239607 Free PMC article.
Phosphorylation of the synthetic hexasaccharide repeating unit is essential for the induction of antibodies to Clostridium difficile PSII cell wall polysaccharide.
Adamo R, Romano MR, Berti F, Leuzzi R, Tontini M, Danieli E, Cappelletti E, Cakici OS, Swennen E, Pinto V, Brogioni B, Proietti D, Galeotti CL, Lay L, Monteiro MA, Scarselli M, Costantino P. Adamo R, et al. Among authors: lay l. ACS Chem Biol. 2012 Aug 17;7(8):1420-8. doi: 10.1021/cb300221f. Epub 2012 Jun 7. ACS Chem Biol. 2012. PMID: 22620974
The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic.
Calloni I, Unione L, Jiménez-Osés G, Corzana F, Del Bino L, Corrado A, Pitirollo O, Colombo C, Lay L, Adamo R, Jiménez-Barbero J. Calloni I, et al. Among authors: lay l. European J Org Chem. 2018 Sep 9;2018(33):4548-4555. doi: 10.1002/ejoc.201801003. Epub 2018 Aug 17. European J Org Chem. 2018. PMID: 30443159 Free PMC article.
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