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Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer.
Matuszewska K, Ten Kortenaar S, Pereira M, Santry LA, Petrik D, Lo KM, Bridle BW, Wootton SK, Lawler J, Petrik J. Matuszewska K, et al. Among authors: lawler j. Gynecol Oncol. 2022 Jan;164(1):154-169. doi: 10.1016/j.ygyno.2021.11.006. Epub 2021 Nov 16. Gynecol Oncol. 2022. PMID: 34799137 Free article.
Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.
Russell S, Duquette M, Liu J, Drapkin R, Lawler J, Petrik J. Russell S, et al. Among authors: lawler j. FASEB J. 2015 Feb;29(2):576-88. doi: 10.1096/fj.14-261636. Epub 2014 Nov 13. FASEB J. 2015. PMID: 25395453 Free PMC article.
In this study, we describe a novel treatment approach and mechanism of action with 3TSR and chemotherapy that induces regression of advanced stage EOC and significantly improves survival.-Russell, S., Duquette, M., Liu, J., Drapkin, R., Lawler, J., Petrik, …
In this study, we describe a novel treatment approach and mechanism of action with 3TSR and chemotherapy that induces regression of advanced …
Thrombospondin-based antiangiogenic therapy.
Zhang X, Lawler J. Zhang X, et al. Among authors: lawler j. Microvasc Res. 2007 Sep-Nov;74(2-3):90-9. doi: 10.1016/j.mvr.2007.04.007. Epub 2007 May 6. Microvasc Res. 2007. PMID: 17559888 Free PMC article. Review.
672 results