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HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma.
Koskela H, Li Y, Joutsiniemi T, Muranen T, Isoviita VM, Huhtinen K, Micoli G, Lavikka K, Marchi G, Hietanen S, Virtanen A, Hautaniemi S, Oikkonen J, Hynninen J. Koskela H, et al. Among authors: lavikka k. Gynecol Oncol. 2024 Jan;180:91-98. doi: 10.1016/j.ygyno.2023.11.027. Epub 2023 Dec 6. Gynecol Oncol. 2024. PMID: 38061276 Free article. Clinical Trial.
H&E image analysis pipeline for quantifying morphological features.
Ariotta V, Lehtonen O, Salloum S, Micoli G, Lavikka K, Rantanen V, Hynninen J, Virtanen A, Hautaniemi S. Ariotta V, et al. Among authors: lavikka k. J Pathol Inform. 2023 Oct 5;14:100339. doi: 10.1016/j.jpi.2023.100339. eCollection 2023. J Pathol Inform. 2023. PMID: 37915837 Free PMC article.
Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S. Lahtinen A, et al. Among authors: lavikka k. Cancer Cell. 2023 Jun 12;41(6):1103-1117.e12. doi: 10.1016/j.ccell.2023.04.017. Epub 2023 May 18. Cancer Cell. 2023. PMID: 37207655 Free article.
A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids.
Senkowski W, Gall-Mas L, Falco MM, Li Y, Lavikka K, Kriegbaum MC, Oikkonen J, Bulanova D, Pietras EJ, Voßgröne K, Chen YJ, Erkan EP, Dai J, Lundgren A, Grønning Høg MK, Larsen IM, Lamminen T, Kaipio K, Huvila J, Virtanen A, Engelholm L, Christiansen P, Santoni-Rugiu E, Huhtinen K, Carpén O, Hynninen J, Hautaniemi S, Vähärautio A, Wennerberg K. Senkowski W, et al. Among authors: lavikka k. Dev Cell. 2023 Jun 19;58(12):1106-1121.e7. doi: 10.1016/j.devcel.2023.04.012. Epub 2023 May 5. Dev Cell. 2023. PMID: 37148882 Free PMC article.
Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer.
Perez-Villatoro F, Oikkonen J, Casado J, Chernenko A, Gulhan DC, Tumiati M, Li Y, Lavikka K, Hietanen S, Hynninen J, Haltia UM, Tyrmi JS, Laivuori H, Konstantinopoulos PA, Hautaniemi S, Kauppi L, Färkkilä A. Perez-Villatoro F, et al. Among authors: lavikka k. NPJ Precis Oncol. 2022 Dec 29;6(1):96. doi: 10.1038/s41698-022-00339-8. NPJ Precis Oncol. 2022. PMID: 36581696 Free PMC article.
Prospective Longitudinal ctDNA Workflow Reveals Clinically Actionable Alterations in Ovarian Cancer.
Oikkonen J, Zhang K, Salminen L, Schulman I, Lavikka K, Andersson N, Ojanperä E, Hietanen S, Grénman S, Lehtonen R, Huhtinen K, Carpén O, Hynninen J, Färkkilä A, Hautaniemi S. Oikkonen J, et al. Among authors: lavikka k. JCO Precis Oncol. 2019 May 3;3:PO.18.00343. doi: 10.1200/PO.18.00343. eCollection 2019. JCO Precis Oncol. 2019. PMID: 32914024 Free PMC article.
Anduril 2: upgraded large-scale data integration framework.
Cervera A, Rantanen V, Ovaska K, Laakso M, Nuñez-Fontarnau J, Alkodsi A, Casado J, Facciotto C, Häkkinen A, Louhimo R, Karinen S, Zhang K, Lavikka K, Lyly L, Pal Singh M, Hautaniemi S. Cervera A, et al. Among authors: lavikka k. Bioinformatics. 2019 Oct 1;35(19):3815-3817. doi: 10.1093/bioinformatics/btz133. Bioinformatics. 2019. PMID: 30793160