Latz E - Search Results

1

Defining trained immunity and its role in health and disease.

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Netea MG, et al. Among authors: latz e. Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. Nat Rev Immunol. 2020. PMID: 32132681 Free PMC article. Review.

2

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. Fitzgerald KA, et al. Among authors: latz e. Nat Immunol. 2003 May;4(5):491-6. doi: 10.1038/ni921. Nat Immunol. 2003. PMID: 12692549

3

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. Tamehiro N, et al. Among authors: latz e. Biochemistry. 2008 Jun 10;47(23):6138-47. doi: 10.1021/bi800182t. Epub 2008 May 17. Biochemistry. 2008. PMID: 18484747 Free PMC article.

4

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. Halle A, et al. Among authors: latz e. Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11. Nat Immunol. 2008. PMID: 18604209 Free PMC article.

5

Intracellular DNA recognition.

Hornung V, Latz E. Hornung V, et al. Among authors: latz e. Nat Rev Immunol. 2010 Feb;10(2):123-30. doi: 10.1038/nri2690. Nat Rev Immunol. 2010. PMID: 20098460 Review.

6

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. Rathinam VA, et al. Among authors: latz e. Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28. Nat Immunol. 2010. PMID: 20351692 Free PMC article.

7

Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.

Nagpal K, Plantinga TS, Sirois CM, Monks BG, Latz E, Netea MG, Golenbock DT. Nagpal K, et al. Among authors: latz e. J Biol Chem. 2011 Apr 1;286(13):11875-82. doi: 10.1074/jbc.M110.199653. Epub 2011 Feb 16. J Biol Chem. 2011. PMID: 21325272 Free PMC article.

8

Intracellular sensing of microbes and danger signals by the inflammasomes.

Horvath GL, Schrum JE, De Nardo CM, Latz E. Horvath GL, et al. Among authors: latz e. Immunol Rev. 2011 Sep;243(1):119-35. doi: 10.1111/j.1600-065X.2011.01050.x. Immunol Rev. 2011. PMID: 21884172 Free PMC article. Review.

9

Activation and regulation of the inflammasomes.

Latz E, Xiao TS, Stutz A. Latz E, et al. Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452. Nat Rev Immunol. 2013. PMID: 23702978 Free PMC article. Review.

10

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V. Ablasser A, et al. Among authors: latz e. Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29. Nature. 2013. PMID: 24077100 Free PMC article.

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