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Page 1
Targeting the Sphingolipid Rheostat in Gliomas.
Zaibaq F, Dowdy T, Larion M. Zaibaq F, et al. Among authors: larion m. Int J Mol Sci. 2022 Aug 17;23(16):9255. doi: 10.3390/ijms23169255. Int J Mol Sci. 2022. PMID: 36012521 Free PMC article. Review.
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM. Yeung C, et al. Among authors: larion m. Cancer Res. 2019 Oct 1;79(19):5060-5073. doi: 10.1158/0008-5472.CAN-19-0217. Epub 2019 Aug 20. Cancer Res. 2019. PMID: 31431459 Free PMC article.
Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.
Ruiz-Rodado V, Malta TM, Seki T, Lita A, Dowdy T, Celiku O, Cavazos-Saldana A, Li A, Liu Y, Han S, Zhang W, Song H, Davis D, Lee S, Trepel JB, Sabedot TS, Munasinghe J, Yang C, Herold-Mende C, Gilbert MR, Cherukuri MK, Noushmehr H, Larion M. Ruiz-Rodado V, et al. Among authors: larion m. Neuro Oncol. 2020 Apr 15;22(4):480-492. doi: 10.1093/neuonc/noz207. Neuro Oncol. 2020. PMID: 31665443 Free PMC article.
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma.
Ren L, Ruiz-Rodado V, Dowdy T, Huang S, Issaq SH, Beck J, Wang H, Tran Hoang C, Lita A, Larion M, LeBlanc AK. Ren L, et al. Among authors: larion m. Cancer Metab. 2020 Mar 5;8:4. doi: 10.1186/s40170-020-0209-8. eCollection 2020. Cancer Metab. 2020. PMID: 32158544 Free PMC article.
Sphingolipid Pathway as a Source of Vulnerability in IDH1mut Glioma.
Dowdy T, Zhang L, Celiku O, Movva S, Lita A, Ruiz-Rodado V, Gilbert MR, Larion M. Dowdy T, et al. Among authors: larion m. Cancers (Basel). 2020 Oct 10;12(10):2910. doi: 10.3390/cancers12102910. Cancers (Basel). 2020. PMID: 33050528 Free PMC article.
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M. Ruiz-Rodado V, et al. Among authors: larion m. Cancer Metab. 2020 Oct 21;8:23. doi: 10.1186/s40170-020-00229-2. eCollection 2020. Cancer Metab. 2020. PMID: 33101674 Free PMC article.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Lita A, et al. Among authors: larion m. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. Nat Commun. 2021. PMID: 33504762 Free PMC article.
Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies.
Ratnam NM, Sonnemann HM, Frederico SC, Chen H, Hutchinson MND, Dowdy T, Reid CM, Jung J, Zhang W, Song H, Zhang M, Davis D, Larion M, Giles AJ, Gilbert MR. Ratnam NM, et al. Among authors: larion m. Front Oncol. 2021 Jul 15;11:719091. doi: 10.3389/fonc.2021.719091. eCollection 2021. Front Oncol. 2021. PMID: 34336705 Free PMC article.
42 results