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Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation.
Haertle L, Müller T, Lardenoije R, Maierhofer A, Dittrich M, Riemens RJM, Stora S, Roche M, Leber M, Riedel-Heller S, Wagner M, Scherer M, Ravel A, Mircher C, Cieuta-Walti C, Durand S, van de Hove DLA, Hoffmann P, Ramirez A, Haaf T, El Hajj N, Mégarbané A. Haertle L, et al. Among authors: lardenoije r. Clin Epigenetics. 2019 Dec 16;11(1):195. doi: 10.1186/s13148-019-0787-x. Clin Epigenetics. 2019. PMID: 31843015 Free PMC article.
Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood.
Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, Kawalia A, Hoffmann P, Luck T, Riedel-Heller S, Jessen F, Maier W, Wagner M, Hurlemann R, Kenis G, Ali M, Del Sol A, Mastroeni D, Delvaux E, Coleman PD, Mill J, Rutten BPF, Lunnon K, Ramirez A, van den Hove DLA. Lardenoije R, et al. Clin Epigenetics. 2019 Nov 27;11(1):164. doi: 10.1186/s13148-019-0755-5. Clin Epigenetics. 2019. PMID: 31775875 Free PMC article.
No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment.
Bey K, Wolfsgruber S, Karaca I, Wagner H, Lardenoije R, Becker J, Milz E, Kornhuber J, Peters O, Frölich L, Hüll M, Rüther E, Wiltfang J, Riedel-Heller S, Scherer M, Jessen F, Maier W, van den Hove DL, Rutten BP, Wagner M, Ramirez A. Bey K, et al. Among authors: lardenoije r. Epigenomics. 2016 May;8(5):593-8. doi: 10.2217/epi-2015-0014. Epub 2016 Apr 19. Epigenomics. 2016. PMID: 27092400
Epigenetically regulated microRNAs in Alzheimer's disease.
Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. Van den Hove DL, et al. Among authors: lardenoije r. Neurobiol Aging. 2014 Apr;35(4):731-45. doi: 10.1016/j.neurobiolaging.2013.10.082. Epub 2013 Oct 18. Neurobiol Aging. 2014. PMID: 24238656 Review.
Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease.
Paes D, Lardenoije R, Carollo RM, Roubroeks JAY, Schepers M, Coleman P, Mastroeni D, Delvaux E, Pishva E, Lunnon K, Vanmierlo T, van den Hove D, Prickaerts J. Paes D, et al. Among authors: lardenoije r. Neurobiol Aging. 2021 Jan;97:56-64. doi: 10.1016/j.neurobiolaging.2020.10.004. Epub 2020 Oct 9. Neurobiol Aging. 2021. PMID: 33157432 Free article.
The epigenetics of aging and neurodegeneration.
Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, Coleman P, Lemere CA, Hof PR, van den Hove DL, Rutten BP. Lardenoije R, et al. Prog Neurobiol. 2015 Aug;131:21-64. doi: 10.1016/j.pneurobio.2015.05.002. Epub 2015 Jun 11. Prog Neurobiol. 2015. PMID: 26072273 Free PMC article. Review.
Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome.
Kimura R, Lardenoije R, Tomiwa K, Funabiki Y, Nakata M, Suzuki S, Awaya T, Kato T, Okazaki S, Murai T, Heike T, Rutten BPF, Hagiwara M. Kimura R, et al. Among authors: lardenoije r. Neuropsychopharmacology. 2020 Sep;45(10):1627-1636. doi: 10.1038/s41386-020-0675-2. Epub 2020 Apr 18. Neuropsychopharmacology. 2020. PMID: 32303053 Free PMC article.
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, Coleman PD, van den Hove DL, Rutten BP. Fitzsimons CP, et al. Among authors: lardenoije r. Mol Neurodegener. 2014 Jun 25;9:25. doi: 10.1186/1750-1326-9-25. Mol Neurodegener. 2014. PMID: 24964731 Free PMC article. Review.
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