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Most non-canonical proteins uniquely populate the proteome or immunopeptidome.
Ruiz Cuevas MV, Hardy MP, Hollý J, Bonneil É, Durette C, Courcelles M, Lanoix J, Côté C, Staudt LM, Lemieux S, Thibault P, Perreault C, Yewdell JW. Ruiz Cuevas MV, et al. Among authors: lanoix j. Cell Rep. 2021 Mar 9;34(10):108815. doi: 10.1016/j.celrep.2021.108815. Cell Rep. 2021. PMID: 33691108 Free PMC article.
Noncoding regions are the main source of targetable tumor-specific antigens.
Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C. Laumont CM, et al. Among authors: lanoix j. Sci Transl Med. 2018 Dec 5;10(470):eaau5516. doi: 10.1126/scitranslmed.aau5516. Sci Transl Med. 2018. PMID: 30518613
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.
Zhao Q, Laverdure JP, Lanoix J, Durette C, Côté C, Bonneil É, Laumont CM, Gendron P, Vincent K, Courcelles M, Lemieux S, Millar DG, Ohashi PS, Thibault P, Perreault C. Zhao Q, et al. Among authors: lanoix j. Cancer Immunol Res. 2020 Apr;8(4):544-555. doi: 10.1158/2326-6066.CIR-19-0541. Epub 2020 Feb 11. Cancer Immunol Res. 2020. PMID: 32047025
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.
Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CCL, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil É, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, Karamchandani J, Dickson BC, Turcotte R, Wunder JS, Thibault P, Lewis PW, Garcia BA, Mack SC, Taylor MD, Garzia L, Kleinman CL, Jabado N. Khazaei S, et al. Among authors: lanoix j. Cancer Discov. 2020 Dec;10(12):1968-1987. doi: 10.1158/2159-8290.CD-20-0461. Epub 2020 Sep 23. Cancer Discov. 2020. PMID: 32967858 Free PMC article.
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C. Ehx G, et al. Among authors: lanoix j. Immunity. 2021 Apr 13;54(4):737-752.e10. doi: 10.1016/j.immuni.2021.03.001. Epub 2021 Mar 18. Immunity. 2021. PMID: 33740418 Free article.
MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets.
Kovalchik KA, Ma Q, Wessling L, Saab F, Duquette JD, Kubiniok P, Hamelin DJ, Faridi P, Li C, Purcell AW, Jang A, Paramithiotis E, Tognetti M, Reiter L, Bruderer R, Lanoix J, Bonneil É, Courcelles M, Thibault P, Caron E, Sirois I. Kovalchik KA, et al. Among authors: lanoix j. Mol Cell Proteomics. 2022 Jan;21(1):100178. doi: 10.1016/j.mcpro.2021.100178. Epub 2021 Nov 17. Mol Cell Proteomics. 2022. PMID: 34798331 Free PMC article.
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers.
Apavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Thériault C, Laverdure JP, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S, Beauséjour C, Bhatia M, Thibault P, Perreault C. Apavaloaei A, et al. Among authors: lanoix j. Cell Rep. 2022 Aug 16;40(7):111241. doi: 10.1016/j.celrep.2022.111241. Cell Rep. 2022. PMID: 35977509 Free article.
121 results