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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Nordström E, Eriksson F, Sigvardson J, Johannesson M, Kasrayan A, Jones-Kostalla M, Appelkvist P, Söderberg L, Nygren P, Blom M, Rachalski A, Nordenankar K, Zachrisson O, Amandius E, Osswald G, Moge M, Ingelsson M, Bergström J, Lannfelt L, Möller C, Giorgetti M, Fälting J. Nordström E, et al. Among authors: lannfelt l. Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1. Neurobiol Dis. 2021. PMID: 34737044 Free article.
The tau S305S mutation causes frontotemporal dementia with parkinsonism.
Skoglund L, Viitanen M, Kalimo H, Lannfelt L, Jönhagen ME, Ingelsson M, Glaser A, Herva R. Skoglund L, et al. Among authors: lannfelt l. Eur J Neurol. 2008 Feb;15(2):156-61. doi: 10.1111/j.1468-1331.2007.02017.x. Epub 2007 Dec 18. Eur J Neurol. 2008. PMID: 18093153
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. O'Callaghan P, et al. Among authors: lannfelt l. Brain Pathol. 2008 Oct;18(4):548-61. doi: 10.1111/j.1750-3639.2008.00152.x. Epub 2008 Apr 11. Brain Pathol. 2008. PMID: 18422760 Free PMC article.
402 results