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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity.
Rutten L, Swart M, Koornneef A, Bouchier P, Blokland S, Sadi A, Juraszek J, Vijayan A, Schmit-Tillemans S, Verspuij J, Choi Y, Daal CE, Perkasa A, Torres Morales S, Myeni SK, Kikkert M, Tolboom J, van Manen D, Kuipers H, Schuitemaker H, Zahn R, Langedijk JPM. Rutten L, et al. Among authors: langedijk jpm. Sci Rep. 2024 Mar 8;14(1):5735. doi: 10.1038/s41598-024-56293-x. Sci Rep. 2024. PMID: 38459086 Free PMC article.
CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits.
Koornneef A, Vanshylla K, Hardenberg G, Rutten L, Strokappe NM, Tolboom J, Vreugdenhil J, Boer KF, Perkasa A, Blokland S, Burger JA, Huang WC, Lovell JF, van Manen D, Sanders RW, Zahn RC, Schuitemaker H, Langedijk JPM, Wegmann F. Koornneef A, et al. Among authors: langedijk jpm. Nat Commun. 2024 Apr 11;15(1):3128. doi: 10.1038/s41467-024-47492-1. Nat Commun. 2024. PMID: 38605096 Free PMC article.
Absolute quantitation of binding antibodies from clinical samples.
Tang C, Verwilligen A, Sadoff J, Brandenburg B, Sneekes-Vriese E, van den Kerkhof T, Dillen L, Rutten L, Juraszek J, Callewaert K, Janssen S, Huizingh J, Euler Z, Schilperoord T, Verhemeldonck M, Langedijk JPM, Hendriks J, Stieh DJ. Tang C, et al. Among authors: langedijk jpm. NPJ Vaccines. 2024 Jan 6;9(1):8. doi: 10.1038/s41541-023-00793-w. NPJ Vaccines. 2024. PMID: 38184641 Free PMC article.
Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen.
Swart M, Kuipers H, Milder F, Jongeneelen M, Ritschel T, Tolboom J, Muchene L, van der Lubbe J, Izquierdo Gil A, Veldman D, Huizingh J, Verspuij J, Schmit-Tillemans S, Blokland S, de Man M, Roozendaal R, Fox CB, Schuitemaker H, Capelle M, Langedijk JPM, Zahn R, Brandenburg B. Swart M, et al. Among authors: langedijk jpm. NPJ Vaccines. 2023 Nov 11;8(1):176. doi: 10.1038/s41541-023-00772-1. NPJ Vaccines. 2023. PMID: 37952003 Free PMC article.
Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM. Yu X, et al. Among authors: langedijk jpm. PLoS Pathog. 2023 May 1;19(5):e1011308. doi: 10.1371/journal.ppat.1011308. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37126534 Free PMC article.
Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models.
Saeland E, van der Fits L, Bolder R, Heemskerk-van der Meer M, Drijver J, van Polanen Y, Vaneman C, Tettero L, Cox F, Serroyen J, Jorgensen MJ, Langedijk JPM, Schuitemaker H, Callendret B, Zahn RC. Saeland E, et al. Among authors: langedijk jpm. NPJ Vaccines. 2023 Mar 23;8(1):45. doi: 10.1038/s41541-023-00637-7. NPJ Vaccines. 2023. PMID: 36949051 Free PMC article.
Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions.
Milder FJ, Jongeneelen M, Ritschel T, Bouchier P, Bisschop IJM, de Man M, Veldman D, Le L, Kaufmann B, Bakkers MJG, Juraszek J, Brandenburg B, Langedijk JPM. Milder FJ, et al. Among authors: langedijk jpm. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2115379119. doi: 10.1073/pnas.2115379119. Proc Natl Acad Sci U S A. 2022. PMID: 35131851 Free PMC article.
Immunogenicity and protective efficacy of adenoviral and subunit RSV vaccines based on stabilized prefusion F protein in pre-clinical models.
Saeland E, van der Fits L, Bolder R, Heemskerk-van der Meer M, Drijver J, van Polanen Y, Vaneman C, Tettero L, Serroyen J, Schuitemaker H, Callendret B, Langedijk JPM, Zahn RC. Saeland E, et al. Among authors: langedijk jpm. Vaccine. 2022 Feb 7;40(6):934-944. doi: 10.1016/j.vaccine.2021.12.043. Epub 2021 Dec 29. Vaccine. 2022. PMID: 34973849 Free article.
55 results