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Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.
Ho TLF, Lee MY, Goh HC, Ng GYN, Lee JJH, Kannan S, Lim YT, Zhao T, Lim EKH, Phua CZJ, Lee YF, Lim RYX, Ng PJH, Yuan J, Chan DKH, Lieske B, Chong CS, Lee KC, Lum J, Cheong WK, Yeoh KG, Tan KK, Sobota RM, Verma CS, Lane DP, Tam WL, Venkitaraman AR. Ho TLF, et al. Among authors: lane dp. Nat Commun. 2023 Mar 28;14(1):1726. doi: 10.1038/s41467-023-37223-3. Nat Commun. 2023. PMID: 36977662 Free PMC article.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Chandramohan A, Josien H, Yuen TY, Duggal R, Spiegelberg D, Yan L, Juang YA, Ge L, Aronica PG, Kaan HYK, Lim YH, Peier A, Sherborne B, Hochman J, Lin S, Biswas K, Nestor M, Verma CS, Lane DP, Sawyer TK, Garbaccio R, Henry B, Kannan S, Brown CJ, Johannes CW, Partridge AW. Chandramohan A, et al. Among authors: lane dp. Nat Commun. 2024 Jan 12;15(1):489. doi: 10.1038/s41467-023-43346-4. Nat Commun. 2024. PMID: 38216578 Free PMC article.
Cancer. p53, guardian of the genome.
Lane DP. Lane DP. Nature. 1992 Jul 2;358(6381):15-6. doi: 10.1038/358015a0. Nature. 1992. PMID: 1614522 No abstract available.
How cells choose to die.
Lane D. Lane D. Nature. 2001 Nov 1;414(6859):25, 27. doi: 10.1038/35102132. Nature. 2001. PMID: 11689924 No abstract available.
Cancer. A death in the life of p53.
Lane DP. Lane DP. Nature. 1993 Apr 29;362(6423):786-7. doi: 10.1038/362786a0. Nature. 1993. PMID: 8479514 No abstract available.
Awakening angels.
Lane D. Lane D. Nature. 1998 Aug 13;394(6694):616-7. doi: 10.1038/29166. Nature. 1998. PMID: 9716124 No abstract available.
The dominating effect of mutant p53.
Hann BC, Lane DP. Hann BC, et al. Among authors: lane dp. Nat Genet. 1995 Mar;9(3):221-2. doi: 10.1038/ng0395-221. Nat Genet. 1995. PMID: 7773278 No abstract available.
International network of cancer genome projects.
International Cancer Genome Consortium; Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Nicolás P, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, Clément B, de Alava E, Degos F, Ferguson ML, Geary P, Hayes DN, Hudson TJ, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, Shibata T, van de Vijver M, Futreal PA, Aburatani H, Bayés M, Botwell DD, Campbell PJ, Estivill X, Gerhard DS, Grimmond SM, Gut I, Hirst M, López-Otín C, Majumder P, Marra M, McPherson JD, Nakagawa H, Ning Z, Puente XS, Ruan Y, Shibata T, Stratton MR, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Campbell PJ, Flicek P, Getz G, Guigó R, Guo G, Haussler D, Heat… See abstract for full author list ➔ International Cancer Genome Consortium, et al. Among authors: lane dp. Nature. 2010 Apr 15;464(7291):993-8. doi: 10.1038/nature08987. Nature. 2010. PMID: 20393554 Free PMC article.
497 results