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AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Trepte P, Secker C, Olivet J, Blavier J, Kostova S, Maseko SB, Minia I, Silva Ramos E, Cassonnet P, Golusik S, Zenkner M, Beetz S, Liebich MJ, Scharek N, Schütz A, Sperling M, Lisurek M, Wang Y, Spirohn K, Hao T, Calderwood MA, Hill DE, Landthaler M, Choi SG, Twizere JC, Vidal M, Wanker EE. Trepte P, et al. Among authors: landthaler m. Mol Syst Biol. 2024 Apr;20(4):428-457. doi: 10.1038/s44320-024-00019-8. Epub 2024 Mar 11. Mol Syst Biol. 2024. PMID: 38467836 Free PMC article.
Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer.
Babaian A, Rothe K, Girodat D, Minia I, Djondovic S, Milek M, Spencer Miko SE, Wieden HJ, Landthaler M, Morin GB, Mager DL. Babaian A, et al. Among authors: landthaler m. Cell Rep. 2020 May 5;31(5):107611. doi: 10.1016/j.celrep.2020.107611. Cell Rep. 2020. PMID: 32375039 Free article.
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall U, Milek M, Minia I, Vieira-Vieira CH, Müller S, Mastrobuoni G, Hazapis OG, Del Giudice S, Schwefel D, Bley N, Voigt F, Chao JA, Kempa S, Hüttelmaier S, Selbach M, Landthaler M. Zinnall U, et al. Among authors: landthaler m. Nat Commun. 2022 May 18;13(1):2727. doi: 10.1038/s41467-022-30322-7. Nat Commun. 2022. PMID: 35585045 Free PMC article.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Trepte P, Secker C, Kostova S, Maseko SB, Choi SG, Blavier J, Minia I, Ramos ES, Cassonnet P, Golusik S, Zenkner M, Beetz S, Liebich MJ, Scharek N, Schütz A, Sperling M, Lisurek M, Wang Y, Spirohn K, Hao T, Calderwood MA, Hill DE, Landthaler M, Olivet J, Twizere JC, Vidal M, Wanker EE. Trepte P, et al. Among authors: landthaler m. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544560. doi: 10.1101/2023.06.14.544560. bioRxiv. 2023. PMID: 37398436 Free PMC article. Updated. Preprint.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M. Baltz AG, et al. Among authors: landthaler m. Mol Cell. 2012 Jun 8;46(5):674-90. doi: 10.1016/j.molcel.2012.05.021. Mol Cell. 2012. PMID: 22681889 Free article.
An immediate-late gene expression module decodes ERK signal duration.
Uhlitz F, Sieber A, Wyler E, Fritsche-Guenther R, Meisig J, Landthaler M, Klinger B, Blüthgen N. Uhlitz F, et al. Among authors: landthaler m. Mol Syst Biol. 2017 May 3;13(5):928. doi: 10.15252/msb.20177554. Mol Syst Biol. 2017. PMID: 28468958 Free PMC article.
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler E, Mösbauer K, Franke V, Diag A, Gottula LT, Arsiè R, Klironomos F, Koppstein D, Hönzke K, Ayoub S, Buccitelli C, Hoffmann K, Richter A, Legnini I, Ivanov A, Mari T, Del Giudice S, Papies J, Praktiknjo S, Meyer TF, Müller MA, Niemeyer D, Hocke A, Selbach M, Akalin A, Rajewsky N, Drosten C, Landthaler M. Wyler E, et al. Among authors: landthaler m. iScience. 2021 Mar 19;24(3):102151. doi: 10.1016/j.isci.2021.102151. Epub 2021 Feb 6. iScience. 2021. PMID: 33585804 Free PMC article.
742 results