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Cell-free hemoglobin augments acute kidney injury during experimental sepsis.
Shaver CM, Paul MG, Putz ND, Landstreet SR, Kuck JL, Scarfe L, Skrypnyk N, Yang H, Harrison FE, de Caestecker MP, Bastarache JA, Ware LB. Shaver CM, et al. Among authors: landstreet sr. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F922-F929. doi: 10.1152/ajprenal.00375.2018. Epub 2019 Jul 31. Am J Physiol Renal Physiol. 2019. PMID: 31364379 Free PMC article.
Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Miller A, Landstreet SR, Kuck JL, Diamond JM, Lederer DJ, Kawut SM, Palmer SM, Wille KM, Weinacker A, Lama VN, Crespo MM, Orens JB, Shah PD, Hage CA, Cantu E 3rd, Porteous MK, Dhillon G, McDyer J, Bastarache JA, Christie JD, Ware LB; Lung Transplant Outcomes Group (LTOG). Shaver CM, et al. Among authors: landstreet sr. JCI Insight. 2018 Jan 25;3(2):e98546. doi: 10.1172/jci.insight.98546. eCollection 2018 Jan 25. JCI Insight. 2018. PMID: 29367464 Free PMC article.
Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis.
Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA. Meegan JE, et al. Among authors: landstreet sr. PLoS One. 2020 Feb 3;15(2):e0228727. doi: 10.1371/journal.pone.0228727. eCollection 2020. PLoS One. 2020. PMID: 32012200 Free PMC article.
Immune characterization of a xenogeneic human lung cross-circulation support system.
Wu WK, Stier MT, Stokes JW, Ukita R, Patel YJ, Cortelli M, Landstreet SR, Talackine JR, Cardwell NL, Simonds EM, Mentz M, Lowe C, Benson C, Demarest CT, Alexopoulos SP, Shaver CM, Bacchetta M. Wu WK, et al. Among authors: landstreet sr. Sci Adv. 2023 Mar 31;9(13):eade7647. doi: 10.1126/sciadv.ade7647. Epub 2023 Mar 31. Sci Adv. 2023. PMID: 37000867 Free PMC article.
Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88.
Schaaf KR, Landstreet SR, Pugazenthi S, Qian EY, Putz ND, Siderova T, Owen AM, Bohannon JK, Ware LB, Bastarache JA, Shaver CM. Schaaf KR, et al. Among authors: landstreet sr. Am J Physiol Lung Cell Mol Physiol. 2024 Jan 1;326(1):L29-L38. doi: 10.1152/ajplung.00123.2023. Epub 2023 Nov 22. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 37991487 Free article.
MicroRNA-223 coordinates cholesterol homeostasis.
Vickers KC, Landstreet SR, Levin MG, Shoucri BM, Toth CL, Taylor RC, Palmisano BT, Tabet F, Cui HL, Rye KA, Sethupathy P, Remaley AT. Vickers KC, et al. Among authors: landstreet sr. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14518-23. doi: 10.1073/pnas.1215767111. Epub 2014 Sep 22. Proc Natl Acad Sci U S A. 2014. PMID: 25246565 Free PMC article.
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