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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.
Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR. Louphrasitthiphol P, et al. Among authors: lambert jp. Mol Cell. 2020 Aug 6;79(3):472-487.e10. doi: 10.1016/j.molcel.2020.05.025. Epub 2020 Jun 11. Mol Cell. 2020. PMID: 32531202 Free PMC article.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Filippakopoulos P, et al. Among authors: lambert jp. Cell. 2012 Mar 30;149(1):214-31. doi: 10.1016/j.cell.2012.02.013. Cell. 2012. PMID: 22464331 Free PMC article.
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P. Picaud S, et al. Among authors: lambert jp. Sci Adv. 2016 Oct 12;2(10):e1600760. doi: 10.1126/sciadv.1600760. eCollection 2016 Oct. Sci Adv. 2016. PMID: 27757418 Free PMC article.
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P. Savitsky P, et al. Among authors: lambert jp. Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014. Cell Rep. 2016. PMID: 27926874 Free PMC article.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC. Lambert JP, et al. Mol Cell. 2019 Feb 7;73(3):621-638.e17. doi: 10.1016/j.molcel.2018.11.006. Epub 2018 Dec 13. Mol Cell. 2019. PMID: 30554943 Free PMC article.
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.
Herbert K, Binet R, Lambert JP, Louphrasitthiphol P, Kalkavan H, Sesma-Sanz L, Robles-Espinoza CD, Sarkar S, Suer E, Andrews S, Chauhan J, Roberts ND, Middleton MR, Gingras AC, Masson JY, Larue L, Falletta P, Goding CR. Herbert K, et al. Among authors: lambert jp. Genes Dev. 2019 Mar 1;33(5-6):310-332. doi: 10.1101/gad.314633.118. Epub 2019 Feb 25. Genes Dev. 2019. PMID: 30804224 Free PMC article.
Emerging tools to investigate bromodomain functions.
Kougnassoukou Tchara PE, Filippakopoulos P, Lambert JP. Kougnassoukou Tchara PE, et al. Among authors: lambert jp. Methods. 2020 Dec 1;184:40-52. doi: 10.1016/j.ymeth.2019.11.003. Epub 2019 Nov 11. Methods. 2020. PMID: 31726225 Review.
TBX2 controls a proproliferative gene expression program in melanoma.
Lu S, Louphrasitthiphol P, Goradia N, Lambert JP, Schmidt J, Chauhan J, Rughani MG, Larue L, Wilmanns M, Goding CR. Lu S, et al. Among authors: lambert jp. Genes Dev. 2021 Dec 1;35(23-24):1657-1677. doi: 10.1101/gad.348746.121. Epub 2021 Nov 24. Genes Dev. 2021. PMID: 34819350 Free PMC article.
The MITF regulatory network in melanoma.
Chauhan JS, Hölzel M, Lambert JP, Buffa FM, Goding CR. Chauhan JS, et al. Among authors: lambert jp. Pigment Cell Melanoma Res. 2022 Sep;35(5):517-533. doi: 10.1111/pcmr.13053. Epub 2022 Jul 9. Pigment Cell Melanoma Res. 2022. PMID: 35771179 Free PMC article.
151 results