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Changes in the concentration of EGFR-mutated plasma DNA in the first hours of targeted therapy allow the prediction of tumor response in patients with EGFR-driven lung cancer.
Moiseyenko FV, Kuligina ES, Zhabina AS, Belukhin SA, Laidus TA, Martianov AS, Zagorodnev KA, Sokolova TN, Chuinyshena SA, Kholmatov MM, Artemieva EV, Stepanova EO, Shuginova TN, Volkov NM, Yanus GA, Imyanitov EN. Moiseyenko FV, et al. Among authors: laidus ta. Int J Clin Oncol. 2022 May;27(5):850-862. doi: 10.1007/s10147-022-02128-6. Epub 2022 Feb 16. Int J Clin Oncol. 2022. PMID: 35171360 Free PMC article.
Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma.
Kuligina E, Moiseyenko F, Belukhin S, Stepanova E, Zakharova M, Chernobrivtseva V, Aliev I, Sharabura T, Moiseyenko V, Aleksakhina S, Laidus T, Martianov A, Kholmatov M, Whitehead A, Yanus G, Imyanitov E. Kuligina E, et al. World J Clin Oncol. 2021 Dec 24;12(12):1215-1226. doi: 10.5306/wjco.v12.i12.1215. World J Clin Oncol. 2021. PMID: 35070740 Free PMC article.
Content of circulating tumor DNA depends on the tumor type and the dynamics of tumor size, but is not influenced significantly by physical exercise, time of the day or recent meal.
Kuligina ES, Meerovich R, Zagorodnev KA, Kholmatov MM, Sokolova TN, Laidus TA, Romanko AA, Martianov AS, Anisimova MO, Zaitseva OA, Yatsuk OS, Yanus GA, Imyanitov EN. Kuligina ES, et al. Among authors: laidus ta. Cancer Genet. 2021 Aug;256-257:165-178. doi: 10.1016/j.cancergen.2021.05.014. Epub 2021 May 28. Cancer Genet. 2021. PMID: 34186498