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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Zhao Z, Wolkenberg SE, Sanderson PE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM. Zhao Z, et al. Among authors: lai mt. Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. doi: 10.1016/j.bmcl.2007.11.085. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18083561
Purification of untagged HIV-1 reverse transcriptase by affinity chromatography.
Lu M, Ngo W, Mei Y, Munshi V, Burlein C, Loughran MH, Williams PD, Hazuda DJ, Miller MD, Grobler JA, Diamond TL, Lai MT. Lu M, et al. Among authors: lai mt. Protein Expr Purif. 2010 Jun;71(2):231-9. doi: 10.1016/j.pep.2010.01.001. Epub 2010 Jan 8. Protein Expr Purif. 2010. PMID: 20060474
Assessment of the susceptibility of mutant HIV-1 to antiviral agents.
Wang YJ, McKenna PM, Hrin R, Felock P, Lu M, Jones KG, Coburn CA, Grobler JA, Hazuda DJ, Miller MD, Lai MT. Wang YJ, et al. Among authors: lai mt. J Virol Methods. 2010 May;165(2):230-7. doi: 10.1016/j.jviromet.2010.02.002. Epub 2010 Feb 11. J Virol Methods. 2010. PMID: 20153375
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Lai MT, Lu M, Felock PJ, Hrin RC, Wang YJ, Yan Y, Munshi S, McGaughey GB, Tynebor RM, Tucker TJ, Williams TM, Grobler JA, Hazuda DJ, McKenna PM, Miller MD. Lai MT, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4812-24. doi: 10.1128/AAC.00829-10. Epub 2010 Aug 30. Antimicrob Agents Chemother. 2010. PMID: 20805392 Free PMC article.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Lu M, Felock PJ, Munshi V, Hrin RC, Wang YJ, Yan Y, Munshi S, McGaughey GB, Gomez R, Anthony NJ, Williams TM, Grobler JA, Hazuda DJ, McKenna PM, Miller MD, Lai MT. Lu M, et al. Among authors: lai mt. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35. doi: 10.1128/AAC.00102-12. Epub 2012 Mar 5. Antimicrob Agents Chemother. 2012. PMID: 22391531 Free PMC article.
In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor.
Lai MT, Feng M, Falgueyret JP, Tawa P, Witmer M, DiStefano D, Li Y, Burch J, Sachs N, Lu M, Cauchon E, Campeau LC, Grobler J, Yan Y, Ducharme Y, Côté B, Asante-Appiah E, Hazuda DJ, Miller MD. Lai MT, et al. Antimicrob Agents Chemother. 2014;58(3):1652-63. doi: 10.1128/AAC.02403-13. Epub 2013 Dec 30. Antimicrob Agents Chemother. 2014. PMID: 24379202 Free PMC article.
172 results