Lai K - Search Results

1

GALK inhibitors for classic galactosemia.

Lai K, Boxer MB, Marabotti A. Lai K, et al. Future Med Chem. 2014 Jun;6(9):1003-15. doi: 10.4155/fmc.14.43. Future Med Chem. 2014. PMID: 25068984 Review.

2

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.

Slepak TI, Tang M, Slepak VZ, Lai K. Slepak TI, et al. Among authors: lai k. Mol Genet Metab. 2007 Sep-Oct;92(1-2):78-87. doi: 10.1016/j.ymgme.2007.06.005. Epub 2007 Jul 20. Mol Genet Metab. 2007. PMID: 17643331 Free PMC article.

3

Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.

Tang M, Odejinmi SI, Allette YM, Vankayalapati H, Lai K. Tang M, et al. Among authors: lai k. Bioorg Med Chem. 2011 Oct 1;19(19):5886-95. doi: 10.1016/j.bmc.2011.08.012. Epub 2011 Aug 16. Bioorg Med Chem. 2011. PMID: 21903402 Free PMC article.

4

Innovative therapy for Classic Galactosemia - tale of two HTS.

Tang M, Odejinmi SI, Vankayalapati H, Wierenga KJ, Lai K. Tang M, et al. Among authors: lai k. Mol Genet Metab. 2012 Jan;105(1):44-55. doi: 10.1016/j.ymgme.2011.09.028. Epub 2011 Oct 1. Mol Genet Metab. 2012. PMID: 22018723 Free PMC article. Review.

5

Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.

Odejinmi S, Rascon R, Tang M, Vankayalapati H, Lai K. Odejinmi S, et al. Among authors: lai k. ACS Med Chem Lett. 2011 Sep 8;2(9):667-672. doi: 10.1021/ml200131j. ACS Med Chem Lett. 2011. PMID: 22125663 Free PMC article.

6

Correlation assessment among clinical phenotypes, expression analysis and molecular modeling of 14 novel variations in the human galactose-1-phosphate uridylyltransferase gene.

Tang M, Facchiano A, Rachamadugu R, Calderon F, Mao R, Milanesi L, Marabotti A, Lai K. Tang M, et al. Among authors: lai k. Hum Mutat. 2012 Jul;33(7):1107-15. doi: 10.1002/humu.22093. Epub 2012 Apr 30. Hum Mutat. 2012. PMID: 22461411 Free PMC article.

7

Subfertility and growth restriction in a new galactose-1 phosphate uridylyltransferase (GALT) - deficient mouse model.

Tang M, Siddiqi A, Witt B, Yuzyuk T, Johnson B, Fraser N, Chen W, Rascon R, Yin X, Goli H, Bodamer OA, Lai K. Tang M, et al. Among authors: lai k. Eur J Hum Genet. 2014 Oct;22(10):1172-9. doi: 10.1038/ejhg.2014.12. Epub 2014 Feb 19. Eur J Hum Genet. 2014. PMID: 24549051 Free PMC article.

8

Structure activity relationships of human galactokinase inhibitors.

Liu L, Tang M, Walsh MJ, Brimacombe KR, Pragani R, Tanega C, Rohde JM, Baker HL, Fernandez E, Blackman B, Bougie JM, Leister WH, Auld DS, Shen M, Lai K, Boxer MB. Liu L, et al. Among authors: lai k. Bioorg Med Chem Lett. 2015 Feb 1;25(3):721-7. doi: 10.1016/j.bmcl.2014.11.061. Epub 2014 Dec 13. Bioorg Med Chem Lett. 2015. PMID: 25553891

9

Effect of genotype on galactose-1-phosphate in classic galactosemia patients.

Yuzyuk T, Balakrishnan B, Schwarz EL, De Biase I, Hobert J, Longo N, Mao R, Lai K, Pasquali M. Yuzyuk T, et al. Among authors: lai k. Mol Genet Metab. 2018 Nov;125(3):258-265. doi: 10.1016/j.ymgme.2018.08.012. Epub 2018 Aug 23. Mol Genet Metab. 2018. PMID: 30172461

10

Discovery of novel inhibitors of human galactokinase by virtual screening.

Hu X, Zhang YQ, Lee OW, Liu L, Tang M, Lai K, Boxer MB, Hall MD, Shen M. Hu X, et al. Among authors: lai k. J Comput Aided Mol Des. 2019 Apr;33(4):405-417. doi: 10.1007/s10822-019-00190-3. Epub 2019 Feb 26. J Comput Aided Mol Des. 2019. PMID: 30806949 Free PMC article.

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