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Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist.
Yu J, Kumar A, Zhang X, Martin C, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Yu J, et al. Among authors: laeremans t. bioRxiv [Preprint]. 2023 Dec 7:2023.12.06.570395. doi: 10.1101/2023.12.06.570395. bioRxiv. 2023. PMID: 38106026 Free PMC article. Preprint.
Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs.
Laeremans T, Sands ZA, Claes P, De Blieck A, De Cesco S, Triest S, Busch A, Felix D, Kumar A, Jaakola VP, Menet C. Laeremans T, et al. Front Mol Biosci. 2022 May 23;9:863099. doi: 10.3389/fmolb.2022.863099. eCollection 2022. Front Mol Biosci. 2022. PMID: 35677880 Free PMC article. Review.
A topological switch in CFTR modulates channel activity and sensitivity to unfolding.
Scholl D, Sigoillot M, Overtus M, Martinez RC, Martens C, Wang Y, Pardon E, Laeremans T, Garcia-Pino A, Steyaert J, Sheppard DN, Hendrix J, Govaerts C. Scholl D, et al. Among authors: laeremans t. Nat Chem Biol. 2021 Sep;17(9):989-997. doi: 10.1038/s41589-021-00844-0. Epub 2021 Aug 2. Nat Chem Biol. 2021. PMID: 34341587
43 results