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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J. Demaria M, et al. Among authors: laberge rm. Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11. Dev Cell. 2014. PMID: 25499914 Free PMC article.
p53: Pro-aging or pro-longevity?
de Keizer PL, Laberge RM, Campisi J. de Keizer PL, et al. Among authors: laberge rm. Aging (Albany NY). 2010 Jul;2(7):377-9. doi: 10.18632/aging.100178. Aging (Albany NY). 2010. PMID: 20657035 Free PMC article. No abstract available.
Lamin B1 loss is a senescence-associated biomarker.
Freund A, Laberge RM, Demaria M, Campisi J. Freund A, et al. Among authors: laberge rm. Mol Biol Cell. 2012 Jun;23(11):2066-75. doi: 10.1091/mbc.E11-10-0884. Epub 2012 Apr 11. Mol Biol Cell. 2012. PMID: 22496421 Free PMC article.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J. Laberge RM, et al. Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6. Nat Cell Biol. 2015. PMID: 26147250 Free PMC article.
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. Chang J, et al. Among authors: laberge rm. Nat Med. 2016 Jan;22(1):78-83. doi: 10.1038/nm.4010. Epub 2015 Dec 14. Nat Med. 2016. PMID: 26657143 Free PMC article.
Oxidation resistance 1 is a novel senolytic target.
Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Zhang X, et al. Among authors: laberge rm. Aging Cell. 2018 Aug;17(4):e12780. doi: 10.1111/acel.12780. Epub 2018 May 15. Aging Cell. 2018. PMID: 29766639 Free PMC article.
26 results