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CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease.
Sharma A, Boelens JJ, Cancio M, Hankins JS, Bhad P, Azizy M, Lewandowski A, Zhao X, Chitnis S, Peddinti R, Zheng Y, Kapoor N, Ciceri F, Maclachlan T, Yang Y, Liu Y, Yuan J, Naumann U, Yu VWC, Stevenson SC, De Vita S, LaBelle JL. Sharma A, et al. Among authors: labelle jl. N Engl J Med. 2023 Aug 31;389(9):820-832. doi: 10.1056/NEJMoa2215643. N Engl J Med. 2023. PMID: 37646679 Clinical Trial.
Curative Therapies for Sickle Cell Disease.
Kaviany S, Barnawi Z, LaBelle J. Kaviany S, et al. Pediatr Ann. 2024 Feb;53(2):e56-e61. doi: 10.3928/19382359-20231205-06. Epub 2024 Feb 1. Pediatr Ann. 2024. PMID: 38302122 Review.
Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma.
Schnorenberg MR, Hawley KM, Thomas-Toth AT, Watkins EA, Tian Y, Ting JM, Leak LB, Kucera IM, Raczy MM, Kung AL, Hubbell JA, Tirrell MV, LaBelle JL. Schnorenberg MR, et al. Among authors: labelle jl. ACS Nano. 2023 Dec 12;17(23):23374-23390. doi: 10.1021/acsnano.3c04112. Epub 2023 Sep 9. ACS Nano. 2023. PMID: 37688780 Free PMC article.
Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.
Hawley KM, Eclov RJ, Schnorenberg MR, Tian Y, Shah RN, Thomas-Toth AT, Fefferman M, Bird GH, Walensky LD, Tirrell MV, LaBelle JL. Hawley KM, et al. Among authors: labelle jl. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2209044119. doi: 10.1073/pnas.2209044119. Epub 2022 Oct 13. Proc Natl Acad Sci U S A. 2022. PMID: 36227917 Free PMC article.
A phase 1 trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second allo-SCT.
Tran MC, Hasan Y, Wang A, Yenice K, Partouche J, Stock W, Larson RA, Kosuri S, LaBelle JL, Kline J, Riedell PA, Artz AS, Weichselbaum R, Bishop MR, Aydogan B, Liu H. Tran MC, et al. Among authors: labelle jl. Blood Adv. 2023 Feb 14;7(3):285-292. doi: 10.1182/bloodadvances.2022007530. Blood Adv. 2023. PMID: 35851593 Free PMC article. Clinical Trial.
Efficacy of post-induction therapy for high-risk neuroblastoma patients with end-induction residual disease.
Desai AV, Applebaum MA, Karrison TG, Oppong A, Yuan C, Berg KR, MacQuarrie K, Sokol E, Hall AG, Pinto N, Wolfe I, Mody R, Shusterman S, Smith V, Foster JH, Nassin M, LaBelle JL, Bagatell R, Cohn SL. Desai AV, et al. Among authors: labelle jl. Cancer. 2022 Aug 1;128(15):2967-2977. doi: 10.1002/cncr.34263. Epub 2022 Jun 6. Cancer. 2022. PMID: 35665495 Free PMC article.
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