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Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839.
Sparve E, Quartino AL, Lüttgen M, Tunblad K, Gårdlund AT, Fälting J, Alexander R, Kågström J, Sjödin L, Bulgak A, Al-Saffar A, Bridgland-Taylor M, Pollard C, Swedberg MD, Vik T, Paulsson B. Sparve E, et al. Among authors: luttgen m. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78. doi: 10.1124/jpet.114.215202. Epub 2014 Jun 10. J Pharmacol Exp Ther. 2014. PMID: 24917547 Free article. Clinical Trial.
Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers.
Quartino A, Huledal G, Sparve E, Lüttgen M, Bueters T, Karlsson P, Olsson T, Paraskos J, Maltby J, Claeson-Bohnstedt K, Lee CM, Alexander R, Fälting J, Paulsson B. Quartino A, et al. Among authors: luttgen m. Clin Pharmacol Drug Dev. 2014 Sep;3(5):396-405. doi: 10.1002/cpdd.130. Epub 2014 May 26. Clin Pharmacol Drug Dev. 2014. PMID: 27129013 Clinical Trial.
Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters.
Carlsson A, Kuhn P, Luttgen MS, Keomanee-Dizon K, Troncoso P, Corn PG, Kolatkar A, Hicks JB, Logothetis CJ, Zurita AJ. Carlsson A, et al. Among authors: luttgen ms. Clin Cancer Res. 2017 Apr 1;23(7):1722-1732. doi: 10.1158/1078-0432.CCR-16-1355. Epub 2016 Oct 4. Clin Cancer Res. 2017. PMID: 27702818 Free PMC article.
A physical sciences network characterization of circulating tumor cell aggregate transport.
King MR, Phillips KG, Mitrugno A, Lee TR, de Guillebon AM, Chandrasekaran S, McGuire MJ, Carr RT, Baker-Groberg SM, Rigg RA, Kolatkar A, Luttgen M, Bethel K, Kuhn P, Decuzzi P, McCarty OJ. King MR, et al. Among authors: luttgen m. Am J Physiol Cell Physiol. 2015 May 15;308(10):C792-802. doi: 10.1152/ajpcell.00346.2014. Epub 2015 Mar 18. Am J Physiol Cell Physiol. 2015. PMID: 25788574 Free PMC article.
23 results