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Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Sasmal PK, Krishna CV, Adabala SS, Roshaiah M, Rawoof KA, Thadi E, Sukumar KP, Cheera S, Abbineni C, Rao KV, Prasanthi A, Nijhawan K, Jaleel M, Iyer LR, Chaitanya TK, Tiwari NK, Krishna NL, Potluri V, Khanna I, Frimurer TM, Lückmann M, Rist Ø, Elster L, Högberg T. Sasmal PK, et al. Among authors: luckmann m. Bioorg Med Chem Lett. 2015 Feb 15;25(4):887-92. doi: 10.1016/j.bmcl.2014.12.064. Epub 2015 Jan 6. Bioorg Med Chem Lett. 2015. PMID: 25599839
GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Hauge M, Vestmar MA, Husted AS, Ekberg JP, Wright MJ, Di Salvo J, Weinglass AB, Engelstoft MS, Madsen AN, Lückmann M, Miller MW, Trujillo ME, Frimurer TM, Holst B, Howard AD, Schwartz TW. Hauge M, et al. Among authors: luckmann m. Mol Metab. 2014 Oct 24;4(1):3-14. doi: 10.1016/j.molmet.2014.10.002. eCollection 2015 Jan. Mol Metab. 2014. PMID: 25685685 Free PMC article.
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
Barington L, Rummel PC, Lückmann M, Pihl H, Larsen O, Daugvilaite V, Johnsen AH, Frimurer TM, Karlshøj S, Rosenkilde MM. Barington L, et al. Among authors: luckmann m. J Biol Chem. 2016 Jul 29;291(31):16208-20. doi: 10.1074/jbc.M115.706747. Epub 2016 May 19. J Biol Chem. 2016. PMID: 27226537 Free PMC article.
The HETE Is on FFAR1 and Pancreatic Islet Cells.
Trauelsen M, Lückmann M, Frimurer TM, Schwartz TW. Trauelsen M, et al. Among authors: luckmann m. Cell Metab. 2018 Feb 6;27(2):273-275. doi: 10.1016/j.cmet.2018.01.006. Cell Metab. 2018. PMID: 29414682 Free article.
Translating biased signaling in the ghrelin receptor system into differential in vivo functions.
Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B. Mende F, et al. Among authors: luckmann m. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10255-E10264. doi: 10.1073/pnas.1804003115. Epub 2018 Oct 9. Proc Natl Acad Sci U S A. 2018. PMID: 30301804 Free PMC article.
25 results