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Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.
López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E. López-Ureña D, et al. Toxins (Basel). 2019 Jun 17;11(6):348. doi: 10.3390/toxins11060348. Toxins (Basel). 2019. PMID: 31212980 Free PMC article.
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.
Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Quesada-Gómez C, et al. Among authors: lopez urena d. Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15. Infect Immun. 2016. PMID: 26755157 Free PMC article.
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential.
Quesada-Gómez C, Murillo T, Arce G, Badilla-Lobo A, Castro-Peña C, Molina J, López-Ureña D, González-Camacho S, Lomonte B, Chacón-Díaz C, Rodríguez C, Chaves-Olarte E. Quesada-Gómez C, et al. Among authors: lopez urena d. Anaerobe. 2020 Apr;62:102151. doi: 10.1016/j.anaerobe.2020.102151. Epub 2020 Jan 13. Anaerobe. 2020. PMID: 31945474
Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.
Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T, Freire R, Guzmán-Verri C, del Mar Gamboa-Coronado M, Lawley TD, Moreno E, Mulvey MR, de Castro Brito GA, Rodríguez-Cavallini E, Rodríguez C, Chaves-Olarte E. Quesada-Gómez C, et al. J Clin Microbiol. 2015 Apr;53(4):1216-26. doi: 10.1128/JCM.03058-14. Epub 2015 Feb 4. J Clin Microbiol. 2015. PMID: 25653402 Free PMC article.
A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption.
Costa CL, López-Ureña D, de Oliveira Assis T, Ribeiro RA, Silva RO, Rupnik M, Wilcox MH, de Carvalho AF, do Carmo AO, Dias AA, de Carvalho CB, Chaves-Olarte E, Rodríguez C, Quesada-Gómez C, de Castro Brito GA. Costa CL, et al. Among authors: lopez urena d. Anaerobe. 2016 Aug;40:76-84. doi: 10.1016/j.anaerobe.2016.06.005. Epub 2016 Jun 14. Anaerobe. 2016. PMID: 27311833 Free article.
Transforming Growth Factor β1/SMAD Signaling Pathway Activation Protects the Intestinal Epithelium from Clostridium difficile Toxin A-Induced Damage.
Tinoco-Veras CM, Santos AAQA, Stipursky J, Meloni M, Araujo APB, Foschetti DA, López-Ureña D, Quesada-Gómez C, Leitão RFC, Gomes FCA, Brito GAC. Tinoco-Veras CM, et al. Among authors: lopez urena d. Infect Immun. 2017 Sep 20;85(10):e00430-17. doi: 10.1128/IAI.00430-17. Print 2017 Oct. Infect Immun. 2017. PMID: 28784928 Free PMC article.
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements.
Ramírez-Vargas G, López-Ureña D, Badilla A, Orozco-Aguilar J, Murillo T, Rojas P, Riedel T, Overmann J, González G, Chaves-Olarte E, Quesada-Gómez C, Rodríguez C. Ramírez-Vargas G, et al. Among authors: lopez urena d. Sci Rep. 2018 Sep 17;8(1):13951. doi: 10.1038/s41598-018-32390-6. Sci Rep. 2018. PMID: 30224751 Free PMC article.
13 results