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Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease.
Velueta-Viveros M, Martínez-Bailén M, Puerta A, Romero-Hernández LL, Křen V, Merino-Montiel P, Montiel-Smith S, Fernandes MX, Moreno-Vargas AJ, Padrón JM, López Ó, Fernández-Bolaños JG. Velueta-Viveros M, et al. Among authors: lopez o. Bioorg Chem. 2022 Oct;127:105983. doi: 10.1016/j.bioorg.2022.105983. Epub 2022 Jun 25. Bioorg Chem. 2022. PMID: 35779403
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
Evangelista TCS, López Ó, Puerta A, Fernandes MX, Ferreira SB, Padrón JM, Fernández-Bolaños JG, Sydnes MO, Lindbäck E. Evangelista TCS, et al. Among authors: lopez o. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2395-2402. doi: 10.1080/14756366.2022.2117912. J Enzyme Inhib Med Chem. 2022. PMID: 36065944 Free PMC article.
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Roldán-Peña JM, Romero-Real V, Hicke J, Maya I, Franconetti A, Lagunes I, Padrón JM, Petralla S, Poeta E, Naldi M, Bartolini M, Monti B, Bolognesi ML, López Ó, Fernández-Bolaños JG. Roldán-Peña JM, et al. Among authors: lopez o. Eur J Med Chem. 2019 Nov 1;181:111550. doi: 10.1016/j.ejmech.2019.07.053. Epub 2019 Jul 22. Eur J Med Chem. 2019. PMID: 31376562
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease.
de Matos AM, Blázquez-Sánchez MT, Bento-Oliveira A, de Almeida RFM, Nunes R, Lopes PEM, Machuqueiro M, Cristóvão JS, Gomes CM, Souza CS, El Idrissi IG, Colabufo NA, Diniz A, Marcelo F, Oliveira MC, López Ó, Fernandez-Bolaños JG, Dätwyler P, Ernst B, Ning K, Garwood C, Chen B, Rauter AP. de Matos AM, et al. Among authors: lopez o. J Med Chem. 2020 Oct 22;63(20):11663-11690. doi: 10.1021/acs.jmedchem.0c00841. Epub 2020 Oct 13. J Med Chem. 2020. PMID: 32959649 Free article.
1,422 results