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Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis.
Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Rangarajan S, et al. Among authors: kurundkar a. Aging Cell. 2022 Sep;21(9):e13674. doi: 10.1111/acel.13674. Epub 2022 Aug 7. Aging Cell. 2022. PMID: 35934931 Free PMC article.
Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance.
Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ. Hecker L, et al. Among authors: kurundkar d, kurundkar a. Sci Transl Med. 2014 Apr 9;6(231):231ra47. doi: 10.1126/scitranslmed.3008182. Sci Transl Med. 2014. PMID: 24718857 Free PMC article.
Novel Mechanisms for the Antifibrotic Action of Nintedanib.
Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders YY, Ding Q, Antony VB, Zhang J, Zmijewski J, Thannickal VJ. Rangarajan S, et al. Among authors: kurundkar d, kurundkar a. Am J Respir Cell Mol Biol. 2016 Jan;54(1):51-9. doi: 10.1165/rcmb.2014-0445OC. Am J Respir Cell Mol Biol. 2016. PMID: 26072676 Free PMC article.
The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury.
Kurundkar AR, Kurundkar D, Rangarajan S, Locy ML, Zhou Y, Liu RM, Zmijewski J, Thannickal VJ. Kurundkar AR, et al. FASEB J. 2016 Jun;30(6):2135-50. doi: 10.1096/fj.201500173. Epub 2016 Feb 16. FASEB J. 2016. PMID: 26884454 Free PMC article.
RNA interference (RNAi)-mediated knockdown of CCN1 down-regulated the constitutive expression of these profibrotic genes in IPF fibroblasts. TGF-beta1, a known mediator of tissue fibrogenesis, induces gene and protein expression of CCN1 via a mothers against decapen …
RNA interference (RNAi)-mediated knockdown of CCN1 down-regulated the constitutive expression of these profibrotic genes in IPF fibroblasts. …
Redox mechanisms in age-related lung fibrosis.
Kurundkar A, Thannickal VJ. Kurundkar A, et al. Redox Biol. 2016 Oct;9:67-76. doi: 10.1016/j.redox.2016.06.005. Epub 2016 Jun 25. Redox Biol. 2016. PMID: 27394680 Free PMC article. Review.
32 results