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The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23.
Navarro-García JA, Salguero-Bodes R, González-Lafuente L, Martín-Nunes L, Rodríguez-Sánchez E, Bada-Bosch T, Hernández E, Mérida-Herrero E, Praga M, Solís J, Arribas F, Bueno H, Kuro-O M, Fernández-Velasco M, Ruilope LM, Delgado C, Ruiz-Hurtado G. Navarro-García JA, et al. BMC Med. 2022 Jan 19;20(1):14. doi: 10.1186/s12916-021-02209-9. BMC Med. 2022. PMID: 35042527 Free PMC article.
Soluble αKlotho as a candidate for the biomarker of aging.
Koyama D, Sato Y, Aizawa M, Maki T, Kurosawa M, Kuro-o M, Furukawa Y. Koyama D, et al. Biochem Biophys Res Commun. 2015 Nov 27;467(4):1019-25. doi: 10.1016/j.bbrc.2015.10.018. Epub 2015 Oct 14. Biochem Biophys Res Commun. 2015. PMID: 26462468
Differential regulation of renal Klotho and FGFR1 in normal and uremic rats.
Muñoz-Castañeda JR, Herencia C, Pendón-Ruiz de Mier MV, Rodriguez-Ortiz ME, Diaz-Tocados JM, Vergara N, Martínez-Moreno JM, Salmerón MD, Richards WG, Felsenfeld A, Kuro-O M, Almadén Y, Rodríguez M. Muñoz-Castañeda JR, et al. FASEB J. 2017 Sep;31(9):3858-3867. doi: 10.1096/fj.201700006R. Epub 2017 May 17. FASEB J. 2017. PMID: 28515153
The Klotho proteins in health and disease.
Kuro-O M. Kuro-O M. Nat Rev Nephrol. 2019 Jan;15(1):27-44. doi: 10.1038/s41581-018-0078-3. Nat Rev Nephrol. 2019. PMID: 30455427 Review.
288 results