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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF. Hyer ML, et al. Among authors: kuranda m. Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15. Nat Med. 2018. PMID: 29334375
Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
Garcia K, Blank JL, Bouck DC, Liu XJ, Sappal DS, Hather G, Cosmopoulos K, Thomas MP, Kuranda M, Pickard MD, Liu R, Bandi S, Smith PG, Lightcap ES. Garcia K, et al. Among authors: kuranda m. Mol Cancer Ther. 2014 Jun;13(6):1625-35. doi: 10.1158/1535-7163.MCT-13-0634. Epub 2014 Mar 26. Mol Cancer Ther. 2014. PMID: 24672057
Analysis of glycoproteins from Saccharomyces cerevisiae.
Orlean P, Kuranda MJ, Albright CF. Orlean P, et al. Among authors: kuranda mj. Methods Enzymol. 1991;194:682-97. doi: 10.1016/0076-6879(91)94050-m. Methods Enzymol. 1991. PMID: 2005816 No abstract available.
Lysosomal degradation of Asn-linked glycoproteins.
Aronson NN Jr, Kuranda MJ. Aronson NN Jr, et al. Among authors: kuranda mj. FASEB J. 1989 Dec;3(14):2615-22. doi: 10.1096/fasebj.3.14.2531691. FASEB J. 1989. PMID: 2531691 Review.
16 results