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5-HT6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines.
Gałęzowski M, Fabritius CH, Pesonen U, Salo H, Olszak-Płachta M, Czerwińska K, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Obuchowicz R, Korjamo T, Jalava N, Nikiforuk A, Nowak M. Gałęzowski M, et al. Among authors: kuokkanen k. Bioorg Med Chem Lett. 2023 Nov 15;96:129497. doi: 10.1016/j.bmcl.2023.129497. Epub 2023 Oct 6. Bioorg Med Chem Lett. 2023. PMID: 37806499
1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists.
Fabritius CH, Pesonen U, Messinger J, Horvath R, Salo H, Gałęzowski M, Galek M, Stefańska K, Szeremeta-Spisak J, Olszak-Płachta M, Buda A, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Chapman H, Obuchowicz R, Korjamo T, Jalava N, Nowak M. Fabritius CH, et al. Among authors: kuokkanen k. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2610-5. doi: 10.1016/j.bmcl.2016.04.024. Epub 2016 Apr 23. Bioorg Med Chem Lett. 2016. PMID: 27117428
Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models.
Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. Sallinen J, et al. Among authors: kuokkanen k. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. doi: 10.1111/bcpt.12090. Epub 2013 Jun 20. Basic Clin Pharmacol Toxicol. 2013. PMID: 23718812 Free article.
GABAB receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine.
de Miguel E, Vekovischeva O, Kuokkanen K, Vesajoki M, Paasikoski N, Kaskinoro J, Myllymäki M, Lainiola M, Janhunen SK, Hyytiä P, Linden AM, Korpi ER. de Miguel E, et al. Among authors: kuokkanen k. Addict Biol. 2019 Nov;24(6):1191-1203. doi: 10.1111/adb.12688. Epub 2018 Nov 13. Addict Biol. 2019. PMID: 30421860
Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain.
Shahid M, Rinne JO, Scheinin M, Virta J, Marjamäki P, Solin O, Arponen E, Sallinen J, Kuokkanen K, Rouru J. Shahid M, et al. Among authors: kuokkanen k. EJNMMI Res. 2020 Dec 9;10(1):152. doi: 10.1186/s13550-020-00741-y. EJNMMI Res. 2020. PMID: 33296042 Free PMC article.
Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.
Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Akerman KE, Lindstedt K, Pertovaara A. Koivisto A, et al. Among authors: kuokkanen k. Pharmacol Res. 2012 Jan;65(1):149-58. doi: 10.1016/j.phrs.2011.10.006. Epub 2011 Nov 23. Pharmacol Res. 2012. PMID: 22133672
64 results