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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Patel SJ, et al. Among authors: kulkarni rn. Sci Transl Med. 2022 Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320000 Free PMC article.
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Rosen ED, et al. Among authors: kulkarni rn. Mol Cell Biol. 2003 Oct;23(20):7222-9. doi: 10.1128/MCB.23.20.7222-7229.2003. Mol Cell Biol. 2003. PMID: 14517292 Free PMC article.
Soluble factors secreted by T cells promote β-cell proliferation.
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Dirice E, et al. Among authors: kulkarni rn. Diabetes. 2014 Jan;63(1):188-202. doi: 10.2337/db13-0204. Epub 2013 Oct 2. Diabetes. 2014. PMID: 24089508 Free PMC article.
Epigenetic modifiers of islet function and mass.
De Jesus DF, Kulkarni RN. De Jesus DF, et al. Among authors: kulkarni rn. Trends Endocrinol Metab. 2014 Dec;25(12):628-36. doi: 10.1016/j.tem.2014.08.006. Epub 2014 Sep 19. Trends Endocrinol Metab. 2014. PMID: 25246382 Review.
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.
El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ, Kulkarni RN. El Ouaamari A, et al. Among authors: kulkarni rn. J Proteome Res. 2015 Aug 7;14(8):3111-3122. doi: 10.1021/acs.jproteome.5b00587. Epub 2015 Jul 30. J Proteome Res. 2015. PMID: 26151086 Free PMC article.
SerpinB1 Promotes Pancreatic β Cell Proliferation.
El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. El Ouaamari A, et al. Among authors: kulkarni rn. Cell Metab. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015 Dec 15. Cell Metab. 2016. PMID: 26701651 Free PMC article.
295 results