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Interaction of small molecule inhibitors of HIV-1 entry with CCR5.
Seibert C, Ying W, Gavrilov S, Tsamis F, Kuhmann SE, Palani A, Tagat JR, Clader JW, McCombie SW, Baroudy BM, Smith SO, Dragic T, Moore JP, Sakmar TP. Seibert C, et al. Among authors: kuhmann se. Virology. 2006 May 25;349(1):41-54. doi: 10.1016/j.virol.2006.01.018. Epub 2006 Feb 21. Virology. 2006. PMID: 16494916 Free article.
The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors.
Billick E, Seibert C, Pugach P, Ketas T, Trkola A, Endres MJ, Murgolo NJ, Coates E, Reyes GR, Baroudy BM, Sakmar TP, Moore JP, Kuhmann SE. Billick E, et al. Among authors: kuhmann se. J Virol. 2004 Apr;78(8):4134-44. doi: 10.1128/jvi.78.8.4134-4144.2004. J Virol. 2004. PMID: 15047829 Free PMC article.
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.
Trkola A, Kuhmann SE, Strizki JM, Maxwell E, Ketas T, Morgan T, Pugach P, Xu S, Wojcik L, Tagat J, Palani A, Shapiro S, Clader JW, McCombie S, Reyes GR, Baroudy BM, Moore JP. Trkola A, et al. Among authors: kuhmann se. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):395-400. doi: 10.1073/pnas.012519099. Proc Natl Acad Sci U S A. 2002. PMID: 11782552 Free PMC article.
HIV-1 entry inhibitor entrances.
Kuhmann SE, Moore JP. Kuhmann SE, et al. Trends Pharmacol Sci. 2004 Mar;25(3):117-20. doi: 10.1016/j.tips.2004.01.005. Trends Pharmacol Sci. 2004. PMID: 15058280 Review. No abstract available.
22 results