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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.
Frank D, Garnish SE, Sandow JJ, Weir A, Liu L, Clayer E, Meza L, Rashidi M, Cobbold SA, Scutts SR, Doerflinger M, Anderton H, Lawlor KE, Lalaoui N, Kueh AJ, Eng VV, Ambrose RL, Herold MJ, Samson AL, Feltham R, Murphy JM, Ebert G, Pearson JS, Vince JE. Frank D, et al. Among authors: kueh aj. iScience. 2022 Jun 17;25(7):104632. doi: 10.1016/j.isci.2022.104632. eCollection 2022 Jul 15. iScience. 2022. PMID: 35800780 Free PMC article.
Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.
Rohrbeck L, Gong JN, Lee EF, Kueh AJ, Behren A, Tai L, Lessene G, Huang DC, Fairlie WD, Strasser A, Herold MJ. Rohrbeck L, et al. Among authors: kueh aj. Cell Death Differ. 2016 Dec;23(12):2054-2062. doi: 10.1038/cdd.2016.96. Epub 2016 Sep 30. Cell Death Differ. 2016. PMID: 27689874 Free PMC article.
A non-canonical function of Ezh2 preserves immune homeostasis.
Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS. Vasanthakumar A, et al. Among authors: kueh aj. EMBO Rep. 2017 Apr;18(4):619-631. doi: 10.15252/embr.201643237. Epub 2017 Feb 21. EMBO Rep. 2017. PMID: 28223321 Free PMC article.
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.
Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H. Glab JA, et al. Among authors: kueh aj. Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14. Cell Death Differ. 2017. PMID: 28409774 Free PMC article.
CRISPR/Cas9: A tool for immunological research.
Hochheiser K, Kueh AJ, Gebhardt T, Herold MJ. Hochheiser K, et al. Among authors: kueh aj. Eur J Immunol. 2018 Apr;48(4):576-583. doi: 10.1002/eji.201747131. Epub 2018 Feb 26. Eur J Immunol. 2018. PMID: 29415333 Free article. Review.
73 results