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A 6-month inhalation toxicology study in Apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.
Wong ET, Szostak J, Titz B, Lee T, Wong SK, Lavrynenko O, Merg C, Corciulo M, Simicevic J, Auberson M, Peric D, Dulize R, Bornand D, Loh GJ, Lee KM, Zhang J, Miller JH 4th, Schlage WK, Guedj E, Schneider T, Phillips B, Leroy P, Choukrallah MA, Sierro N, Buettner A, Xiang Y, Kuczaj A, Ivanov NV, Luettich K, Vanscheeuwijck P, Peitsch MC, Hoeng J. Wong ET, et al. Among authors: kuczaj a. Arch Toxicol. 2021 May;95(5):1805-1829. doi: 10.1007/s00204-021-03020-4. Epub 2021 May 7. Arch Toxicol. 2021. PMID: 33963423 Free PMC article.
A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke.
Szostak J, Wong ET, Titz B, Lee T, Wong SK, Low T, Lee KM, Zhang J, Kumar A, Schlage WK, Guedj E, Phillips B, Leroy P, Buettner A, Xiang Y, Martin F, Sewer A, Kuczaj A, Ivanov NV, Luettich K, Vanscheeuwijck P, Peitsch MC, Hoeng J. Szostak J, et al. Among authors: kuczaj a. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H604-H631. doi: 10.1152/ajpheart.00613.2019. Epub 2020 Jan 24. Am J Physiol Heart Circ Physiol. 2020. PMID: 31975625 Free article.
Alternatives to Animal Use in Risk Assessment of Mixtures.
Wallace Hayes A, Muriana A, Alzualde A, Fernandez DB, Iskandar A, Peitsch MC, Kuczaj A, Hoeng J. Wallace Hayes A, et al. Among authors: kuczaj a. Int J Toxicol. 2020 Mar/Apr;39(2):165-172. doi: 10.1177/1091581820905088. Epub 2020 Feb 18. Int J Toxicol. 2020. PMID: 32066298 Review.
Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system.
Oldham MJ, Castro N, Zhang J, Lucci F, Kosachevsky P, Rostami AA, Gilman IG, Pithawalla YB, Kuczaj AK, Hoeng J, Lee KM. Oldham MJ, et al. Among authors: kuczaj ak. Toxicol In Vitro. 2020 Sep;67:104870. doi: 10.1016/j.tiv.2020.104870. Epub 2020 Apr 21. Toxicol In Vitro. 2020. PMID: 32330563 Free article.
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE-/- mouse model.
Reumann MK, Schaefer J, Titz B, Aspera-Werz RH, Wong ET, Szostak J, Häussling V, Ehnert S, Leroy P, Tan WT, Kuczaj A, Audretsch C, Springer F, Badke A, Augat P, Quentanilla-Fend L, Martella M, Lee KM, Peitsch MC, Hoeng J, Nussler AK. Reumann MK, et al. Among authors: kuczaj a. Arch Toxicol. 2020 Jun;94(6):2163-2177. doi: 10.1007/s00204-020-02769-4. Epub 2020 May 14. Arch Toxicol. 2020. PMID: 32409933 Free PMC article.
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