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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.
Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN. Miller BC, et al. Among authors: kuchroo jr. Nat Immunol. 2019 Mar;20(3):326-336. doi: 10.1038/s41590-019-0312-6. Epub 2019 Feb 18. Nat Immunol. 2019. PMID: 30778252 Free PMC article.
Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.
Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN. Miller BC, et al. Among authors: kuchroo jr. Nat Immunol. 2019 Nov;20(11):1556. doi: 10.1038/s41590-019-0528-5. Nat Immunol. 2019. PMID: 31582823 Free PMC article.
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH. Tan CL, et al. Among authors: kuchroo jr. J Exp Med. 2021 Jan 4;218(1):e20182232. doi: 10.1084/jem.20182232. J Exp Med. 2021. PMID: 33045061 Free PMC article.
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, Sharpe AH, Singer M. Pauken KE, et al. Among authors: kuchroo jr. J Exp Med. 2021 Apr 5;218(4):e20200920. doi: 10.1084/jem.20200920. J Exp Med. 2021. PMID: 33651880 Free PMC article.
PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection.
Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, Malefyt RW, Christian DA, Sharpe AH, Hunter CA. Perry JA, et al. Among authors: kuchroo jr. Nat Immunol. 2022 May;23(5):743-756. doi: 10.1038/s41590-022-01170-w. Epub 2022 Apr 18. Nat Immunol. 2022. PMID: 35437326 Free PMC article.
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
Bod L, Kye YC, Shi J, Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, Zaghouani S, Christian E, Delorey TM, Mohib K, Xiao S, Slingerland N, Giuliano CJ, Ashenberg O, Li Z, Rothstein DM, Fisher DE, Rozenblatt-Rosen O, Sharpe AH, Quintana FJ, Apetoh L, Regev A, Kuchroo VK. Bod L, et al. Among authors: kuchroo jr. Nature. 2023 Jul;619(7969):348-356. doi: 10.1038/s41586-023-06231-0. Epub 2023 Jun 21. Nature. 2023. PMID: 37344597 Free PMC article.
Prognostic significance of cutaneous immune-related adverse events in patients with melanoma and other cancers on immune checkpoint inhibitors.
Thompson LL, Chang MS, Polyakov NJ, Blum AE, Josephs N, Krasnow NA, Yoon J, Li EB, Molina GE, Said JT, Huang K, Kuchroo JR, Hinton AN, Chen ST. Thompson LL, et al. Among authors: kuchroo jr. J Am Acad Dermatol. 2022 Apr;86(4):886-889. doi: 10.1016/j.jaad.2021.03.024. Epub 2021 Mar 17. J Am Acad Dermatol. 2022. PMID: 33722547 No abstract available.
12 results