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Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling.
Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2207327119. doi: 10.1073/pnas.2207327119. Epub 2022 Nov 7.
Proc Natl Acad Sci U S A. 2022.
PMID: 36343233
Free PMC article.
Antibody targeting of E3 ubiquitin ligases for receptor degradation.
Marei H, Tsai WK, Kee YS, Ruiz K, He J, Cox C, Sun T, Penikalapati S, Dwivedi P, Choi M, Kan D, Saenz-Lopez P, Dorighi K, Zhang P, Kschonsak YT, Kljavin N, Amin D, Kim I, Mancini AG, Nguyen T, Wang C, Janezic E, Doan A, Mai E, Xi H, Gu C, Heinlein M, Biehs B, Wu J, Lehoux I, Harris S, Comps-Agrar L, Seshasayee D, de Sauvage FJ, Grimmer M, Li J, Agard NJ, de Sousa E Melo F.
Marei H, et al. Among authors: kschonsak yt.
Nature. 2022 Oct;610(7930):182-189. doi: 10.1038/s41586-022-05235-6. Epub 2022 Sep 21.
Nature. 2022.
PMID: 36131013
Free PMC article.
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Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Kschonsak YT, Gao X, Miller SE, Hwang S, Marei H, Wu P, Li Y, Ruiz K, Dorighi K, Holokai L, Perampalam P, Tsai WK, Kee YS, Agard NJ, Harris SF, Hannoush RN, de Sousa E Melo F.
Kschonsak YT, et al.
Cell Chem Biol. 2023 Dec 5:S2451-9456(23)00421-X. doi: 10.1016/j.chembiol.2023.11.006. Online ahead of print.
Cell Chem Biol. 2023.
PMID: 38056465
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FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.
Richter KT, Kschonsak YT, Vodicska B, Hoffmann I.
Richter KT, et al. Among authors: kschonsak yt.
Cell Death Differ. 2020 Feb;27(2):758-772. doi: 10.1038/s41418-019-0385-7. Epub 2019 Jul 8.
Cell Death Differ. 2020.
PMID: 31285543
Free PMC article.
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Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
Bärenz F, Kschonsak YT, Meyer A, Jafarpour A, Lorenz H, Hoffmann I.
Bärenz F, et al. Among authors: kschonsak yt.
Mol Biol Cell. 2018 Dec 15;29(26):3105-3118. doi: 10.1091/mbc.E18-02-0115. Epub 2018 Oct 24.
Mol Biol Cell. 2018.
PMID: 30354798
Free PMC article.
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Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation.
Kschonsak YT, Hoffmann I.
Kschonsak YT, et al.
J Cell Sci. 2018 May 21;131(10):jcs214544. doi: 10.1242/jcs.214544.
J Cell Sci. 2018.
PMID: 29669740
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